2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. NEKs
  5. NEKs Degrader

NEKs Degrader

NEKs Isoform Comparison

NEKs Degraders (7):

Cat. No. Product Name Effect Purity
  • HY-172162
    LC-04-045
    		Degrader 99.56%
    LC-04-045 is a NEK7 (NIMA-related kinase 7) molecular glue degrader (MGD). LC-04-045 demonstrates potent activity of NEK7 degradation with a DC50 (half-maximal degradation) of 7 nM and a Dmax (maximum degradation) of 90% in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome. LC-04-045 degrades NEK7 mediated by the ubiquitin-proteasome system (UPS) and relies on the glycine 57 (G57)-containing degron motif in NEK7. LC-04-045 effectively inhibits secretion of IL-1β and IL-18 with IC50s of 33.03 nM and 32.99 nM, respectively. LC-04-045 is potential for inflammatory diseases research.
  • HY-173154A
    NK7-902 TFA
    		Degrader 98.86%
    NK7-902 TFA is a CRBN molecular glue degrader of NEK7. NK7-902 TFA fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 TFA leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 TFA shows activity in murine systems.
  • HY-175452
    MRT-3486
    		Degrader
    MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research.
  • HY-175283
    ABT-002
    		Degrader
    ABT-002 is a molecular glue degrader targeting GSPT1 and NEK7. ABT-002 is promising for research of hepatocellular carcinoma (HCC).
  • HY-177433
    NLRP3 modulator 8
    		Degrader
    NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9  nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.
  • HY-W599279
    ABS-752
    		Degrader
    ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 shows anticancer activity. ABS-752 has the potential for the research of hepatocellular carcinoma.
  • HY-176860
    NEK7 degrader-1
    		Degrader
    NEK7 degrader-1 (Compound 17) is a NEK7 degrader with a DC50 of 0.1  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.