2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. NEKs

NEKs

NIMA–related Kinases; NIMA (never in mitosis gene a)-related Expressed Kinases

NIMA-related Kinases (NEKs) are a class of serine/threonine protein kinases ubiquitous in eukaryotic organisms. NEKs play pivotal roles in cell cycle regulation, including chromosome condensation, mitotic entry, centrosome duplication, and mitotic exit.
The NEK family comprises 11 members in humans (NEK1-NEK11). NEK family members are widely involved in key biological processes such as cell cycle regulation, ciliogenesis, and DNA damage repair, making them potential therapeutic targets for diseases.
Abnormal activation or mutations of NEKs are closely associated with cancers, genetic diseases, neurodegenerative diseases, and other conditions[1][2][3][4].

NEKs Isoform Specific Products:

NEKs Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-153749
    Nek2/Hec1-IN-2
    		98.0%
    Nek2/Hec1-IN-2 (Compound 14) is an inhibitor of Nek2/Hec1. Nek2/Hec1-IN-2 inhibits cancer cell proliferation with IC50 >25 μM.
    Nek2/Hec1-IN-2
  • HY-137046
    Nek2-IN-4
    Nek2-IN-4 is a potent NEK2 inhibitor with an IC50 value of 15 nM. Nek2-IN-4 inhibits cell proliferation. Nek2-IN-4 has the potential for the research of pancreatic cancer.
    Nek2-IN-4
  • HY-176463
    Nek2/Hec1-IN-3
    		Inhibitor
    Nek2/Hec1-IN-3 (Compound 11-28) is a Hec1/Nek2 interaction inhibitor. Nek2/Hec1-IN-3 disrupts Nek2/Hec1 binding and can be used for research of neoplastic diseases.
    Nek2/Hec1-IN-3
  • HY-101029A
    MBM-55S
    		Inhibitor
    MBM-55S is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55S shows antitumor activities, and no obvious toxicity to mice.
    MBM-55S
  • HY-101030
    MBM-17
    		Inhibitor
    MBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice.
    MBM-17
  • HY-168737
    NEK7-IN-2
    		Inhibitor
    NEK7-IN-2 (compound 23) is a potent inhibitor of NLRP3-NEK7 interaction. NEK7-IN-2 can enhance the thermal stability of NEK7 and regulatie NLRP3 inflammasome assembly. NEK7-IN-2 inhibits IL-1β releases.
    NEK7-IN-2
  • HY-117398
    HCI-2184
    		Inhibitor
    HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity.
    HCI-2184
  • HY-120356
    T-1101
    		Inhibitor
    T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.
    T-1101
  • HY-177433
    NLRP3 modulator 8
    		Degrader
    NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9  nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.
    NLRP3 modulator 8
  • HY-150046
    Nek2-IN-6
    Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor.
    Nek2-IN-6
  • HY-174270
    NLRP3-IN-79
    		Inhibitor
    NLRP3-IN-79 (Compound B6) is a selective NLRP3 inflammasome inhibitor with an IC50 value of 10.69 nM. NLRP3-IN-79 blocks the assembly of the NLRP3 inflammasome by disrupting the NEK7-NLRP3 interaction. NLRP3-IN-79 is promising for research of NLRP3-driven inflammatory diseases such as systemic inflammation, peritonitis, and colitis.
    NLRP3-IN-79
  • HY-169933
    NEK7-IN-1
    		Inhibitor
    NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 NEK7 with IC50 <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC50 <50 nM.
    NEK7-IN-1
  • HY-W599279
    ABS-752
    		Degrader
    ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 shows anticancer activity. ABS-752 has the potential for the research of hepatocellular carcinoma.
    ABS-752
  • HY-176860
    NEK7 degrader-1
    		Degrader
    NEK7 degrader-1 (Compound 17) is a NEK7 degrader with a DC50 of 0.1  nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.
    NEK7 degrader-1
  • HY-120330
    Nek2-IN-5
    Nek2-IN-5 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior. Nek2-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Nek2-IN-5
NEKs Isoform Comparison

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