2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Na+/H+ Exchanger (NHE)

Na+/H+ Exchanger (NHE)

Sodium/hydrogen Exchanger; Sodium-hydrogen Exchanger

Na+/H+ exchanger (sodium/hydrogen exchanger, NHE) family exchanges Na+ for H+ according to their concentration gradients, thus promotes the regulation of the stability of cytoplasmic pH and cell volume.

There are nine isoforms of NHE in humans, some NHEs function primarily on the plasma membrane, and others are present on intracellular organelles. NHE1 is expressed in the plasma membrane of virtually all tissues and plays an important role in cardiac health. NHE2 is expressed in the gastrointestinal (GI) tract and contributes to the maintenance of stomach pH and homeostasis, whereas NHE3 predominates in the GI tract and kidneys. NHE4 and NHE5 are abundant in the stomach and brain, respectively. NHE6-9 are expressed in the intracellular compartments of many organ system membranes, but of these NHE8 is the exception and expressed apically.

Na+/H+ Exchanger (NHE) Related Products (44):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W704968
    2-Oxo-zoniporide hydrochloride
    		Inhibitor
    2-Oxo-zoniporide hydrochloride is an oral active sodium-hydrogen exchanger type 1 (NHE-1) inhibitor and can be used for study of myocardial ischemic injury.
    2-Oxo-zoniporide hydrochloride
  • HY-19273A
    Rimeporide hydrochloride
    		Inhibitor
    Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
    Rimeporide hydrochloride
  • HY-W705589
    Rimeporide-15N3 hydrochloride
    		Inhibitor
    Rimeporide-15N3 (hydrochloride) (EMD-87580-15N3 (hydrochloride)) is 15N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
    Rimeporide-<sup>15</sup>N<sub>3</sub> hydrochloride
  • HY-101840AR
    EIPA hydrochloride (Standard)
    		Antagonist
    EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
    EIPA hydrochloride (Standard)