2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Methylenetetrahydrofolate Dehydrogenase (MTHFD)
  5. Methylenetetrahydrofolate Dehydrogenase (MTHFD) Inhibitor

Methylenetetrahydrofolate Dehydrogenase (MTHFD) Inhibitor

Methylenetetrahydrofolate Dehydrogenase (MTHFD) Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-155950
    TH9619
    		Inhibitor 99.33%
    TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity.
  • HY-149828
    MTHFD2-IN-4
    		Inhibitor
    MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer.
  • HY-170361
    MTHFD2-IN-5
    		Inhibitor
    MTHFD2-IN-5 (Compound 16e) is a selective inhibitor for MTHFD2 with an IC50 of 66 nM. MTHFD2-IN-5 inhibits the proliferation of MOLM-14 with a GI50 of 720 nM. MTHFD2-IN-5 exhibits antitumor efficacy in mouse models.
  • HY-172910
    MTHFD2-IN-6
    		Inhibitor
    MTHFD2-IN-6 (compound 41) is a potent and selective MTHFD2 inhibitor. MTHFD2-IN-6 inhibits MTHFD1 and MTHFD2 with IC50s of 19.05 and 1.46 μM, respectively.
  • HY-149825
    MTHFD2-IN-1
    		Inhibitor
    MTHFD2-IN-1 (compound 12) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor.
  • HY-149828A
    MTHFD2-IN-4 sodium
    		Inhibitor
    MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 sodium can be used in research of cancer.
  • HY-149826
    MTHFD2-IN-2
    		Inhibitor
    MTHFD2-IN-2 (compound 13) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor.
  • HY-149827
    MTHFD2-IN-3
    		Inhibitor
    MTHFD2-IN-3 (compound 10) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor.
  • HY-155219
    TH9028
    		Inhibitor
    TH9028 is an inhibitor of MTHFD2 (IC50 = 11 nM) with IC50 values against hMTHFD2, MTHFD2L, and MTHFD1 being 7.97 nM, 27 nM, and 0.5 nM, respectively. TH9028 also exhibits anti-cancer cell proliferation activity.