2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

PDF 3.54 MB

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0726R
    Pilocarpine Hydrochloride (Standard)
    		Agonist
    Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine Hydrochloride (Standard)
  • HY-W739521
    N-Desethyloxybutynin hydrochloride
    		Modulator
    N-Desethyloxybutynin hydrochloride is an active metabolite of Oxybutynin. N-Desethyloxybutynin hydrochloride binds to mAChRs in isolated? human bladder and human parotid gland with pKi values of 8.2 and 8.7, respectively.
    N-Desethyloxybutynin hydrochloride
  • HY-U00001A
    Phenglutarimid hydrochloride
    		Inhibitor
    Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
    Phenglutarimid hydrochloride
  • HY-76569S1
    (R)-Hydroxytolterodine-d14
    		Antagonist
    (R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
    (R)-Hydroxytolterodine-d<sub>14</sub>
  • HY-118356
    WIN 62,577
    		Antagonist
    WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.
    WIN 62,577
  • HY-B1339R
    Dicyclomine hydrochloride (Standard)
    		Inhibitor
    Dicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
    Dicyclomine hydrochloride (Standard)
  • HY-B1132R
    Clidinium bromide (Standard)
    		Antagonist
    Clidinium (bromide) (Standard) is the analytical standard of Clidinium (bromide). This product is intended for research and analytical applications. Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.
    Clidinium bromide (Standard)
  • HY-B0327R
    Irsogladine (Standard)
    		Inhibitor
    Irsogladine (Standard) is the analytical standard of Irsogladine. This product is intended for research and analytical applications. 0
    Irsogladine (Standard)
  • HY-U00139
    Cyclodrine hydrochloride
    		Antagonist
    Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.
    Cyclodrine hydrochloride
  • HY-U00230
    CDD0102
    		Agonist
    CDD0102 is a potent M1 Muscarinic receptor agonist.
    CDD0102
  • HY-U00203
    Tematropium
    		Inhibitor 98.12%
    Tematropium (CDDD3602) is a soft anticholinergics.
    Tematropium
  • HY-U00406
    BTM-1086
    		Modulator
    BTM-1086 is a potent anti-ulcer and gastric secretory inhibiting agent.
    BTM-1086
  • HY-U00104
    YM-46303
    		Antagonist
    YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.
    YM-46303
  • HY-U00415
    Benzamide Derivative 1
    		Antagonist
    Benzamide Derivative 1 is a benzamide derivative from patent EP0213775A1, compound 18. Benzamide Derivative 1 may be useful in treatment of gastrointestinal disorders.
    Benzamide Derivative 1
  • HY-U00184
    Timepidium bromide
    		Inhibitor
    Timepidium bromide (Sesden; SA504) is an anticholinergic agent.
    Timepidium bromide
  • HY-U00316
    Vinconate
    		Activator
    Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.
    Vinconate
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.