2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101586A
    Alvameline maleate
    		Antagonist
    Alvameline (Lu 25-109) maleate is a partial agonist of M1 and an antagonist of M2/M3. Alvameline maleate competitively antagonizes contractions induced by ammonium chloride (HY-Y1269) and electrical field stimulation in human detrusor muscle, indicating its potential application in regulating bladder function. Additionally, alvameline maleate can improve cognitive function following traumatic brain injury in rats.
    Alvameline maleate
  • HY-12100R
    Umeclidinium bromide (Standard)
    		Antagonist
    Umeclidinium (bromide) (Standard) is the analytical standard of Umeclidinium (bromide). This product is intended for research and analytical applications. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
    Umeclidinium bromide (Standard)
  • HY-101368A
    WIN 64338 hydrochloride
    		Antagonist
    WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM).
    WIN 64338 hydrochloride
  • HY-105182S1
    Xanomeline-d3
    		Agonist
    Xanomeline-d3 (LY-246708-d3) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.
    Xanomeline-d<sub>3</sub>
  • HY-A0016S3
    Dronedarone-d6
    		Inhibitor
    Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
    Dronedarone-d<sub>6</sub>
  • HY-112076R
    Atropine methyl bromide (Standard)
    		Antagonist
    Atropine methyl (bromide) (Standard) is the analytical standard of Atropine methyl (bromide). This product is intended for research and analytical applications. Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine.
    Atropine methyl bromide (Standard)
  • HY-107922R
    Ethopropazine hydrochloride (Standard)
    		Antagonist
    Ethopropazine (hydrochloride) (Standard) is the analytical standard of Ethopropazine (hydrochloride) (HY-107922). This product is intended for research and analytical applications. Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease.
    Ethopropazine hydrochloride (Standard)
  • HY-U00055
    Temiverine hydrochloride
    		Antagonist
    Temiverine hydrochloride is a synthesized agent that is expected to have anticholinergic action. Temiverine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Temiverine hydrochloride
  • HY-U00067
    Ambutonium bromide
    		Antagonist
    Ambutonium bromide is an acetylcholine antagonist.
    Ambutonium bromide
  • HY-U00038
    ENS-163 phosphate
    		Agonist
    ENS-163 phosphate is a selective muscarinic M1 receptor agonist.
    ENS-163 phosphate
  • HY-U00030
    Rispenzepine
    		Antagonist
    Rispenzepine is a novel antimuscarinic compound with a preferential action at M1, and M3 receptor subtypes.
    Rispenzepine
  • HY-101694
    Siltenzepine
    		Antagonist
    Siltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po).
    Siltenzepine
  • HY-101743
    Elucaine
    		Antagonist
    Elucaine is a muscarinic acetylcholine receptor antagonist with anti-ulcerative activity.
    Elucaine
  • HY-A0034R
    Solifenacin (Standard)
    		Antagonist
    Solifenacin (Standard) is the analytical standard of Solifenacin. This product is intended for research and analytical applications. Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
    Solifenacin (Standard)
  • HY-121404B
    Muscarine tosylate
    		Agonist
    Muscarine ((+)-Muscarine) tosylate is an agonist of prototype mAChR. Muscarine tosylate is a toxin that can stimulate the parasympathetic nervous system.
    Muscarine tosylate
  • HY-119953
    BIBN-99
    		Antagonist
    BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury.
    BIBN-99
  • HY-105182R
    Xanomeline (Standard)
    		Agonist
    Xanomeline (Standard) is the analytical standard of Xanomeline. This product is intended for research and analytical applications. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia.
    Xanomeline (Standard)
  • HY-B0662A
    Imidafenacin hydrochloride
    		Inhibitor
    Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM.
    Imidafenacin hydrochloride
  • HY-19652A
    (S)-Oxybutynin hydrochloride
    		Antagonist
    (S)-Oxybutynin (Esoxybutynin) hydrochloride is a potent muscarinic receptor antagonist.
    (S)-Oxybutynin hydrochloride
  • HY-N7247R
    Thiochrome (Standard)
    		Activator
    Thiochrome (Standard) is the analytical standard of Thiochrome. This product is intended for research and analytical applications. Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors.
    Thiochrome (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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