2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101586
    Alvameline
    		Antagonist
    Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.
    Alvameline
  • HY-127022A
    Anisodine hydrobromide
    		Inhibitor
    Anisodine (Daturamine) hydrobromide is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine hydrobromide inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine hydrobromide leads to decreased aspartate levels during hypoxia.
    Anisodine hydrobromide
  • HY-W708197
    Tolterodine dimer
    		Control
    Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.
    Tolterodine dimer
  • HY-B0954R
    Oxyphencyclimine hydrochloride (Standard)
    		Antagonist
    Oxyphencyclimine (hydrochloride) (Standard) is the analytical standard of Oxyphencyclimine (hydrochloride). This product is intended for research and analytical applications. A new tertiary amine, Oxyphencyclimine hydrochloride，has been investigated for its effects on the peripheral parasympathetic system.
    Oxyphencyclimine hydrochloride (Standard)
  • HY-126184
    Revatropate
    		Antagonist
    Revatropate is an antimuscarinic compound. Revatropate has a much greater inhibitory effect on M1 and M3 receptors than on the M2 subtype. Revatropate is used in the study of urge urinary incontinence and functional bowel disorders.
    Revatropate
  • HY-101086R
    Acetylcholine iodide (Standard)
    Acetylcholine (iodide) (Standard) is the analytical standard of Acetylcholine (iodide). This product is intended for research and analytical applications. Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system.
    Acetylcholine iodide (Standard)
  • HY-14541A
    Olanzapine hydrochloride
    		Antagonist
    Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine hydrochloride is an atypical antipsychotic.
    Olanzapine hydrochloride
  • HY-119333
    NNC 11-1607
    		Agonist
    NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia.
    NNC 11-1607
  • HY-134081
    Desiodomethyl 4-DAMP
    		Antagonist
    Desiodomethyl 4-DAMP is a muscarinic receptor antagonist.
    Desiodomethyl 4-DAMP
  • HY-12980R
    Batefenterol (Standard)
    		Antagonist
    Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
    Batefenterol (Standard)
  • HY-121773
    Metoquizine
    Metoquizine is an anticholinergic agent.
    Metoquizine
  • HY-149504
    3-Hydroxy darifenacin
    		Antagonist
    3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
    3-Hydroxy darifenacin
  • HY-76569R
    Desfesoterodine (Standard)
    		Antagonist
    Desfesoterodine (Standard) is the analytical standard of Desfesoterodine. This product is intended for research and analytical applications. Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
    Desfesoterodine (Standard)
  • HY-122510A
    Atropine oxide hydrochloride
    		Antagonist
    Atropine Oxide (Atropine oxidation) hydrochloride, a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings.
    Atropine oxide hydrochloride
  • HY-15851S2
    Revefenacin-d3
    		Antagonist
    Revefenacin-d3 (TD-4208-d3) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
    Revefenacin-d<sub>3</sub>
  • HY-B1667R
    Isopropamide iodide (Standard)
    Isopropamide (iodide) (Standard) is the analytical standard of Isopropamide (iodide). This product is intended for research and analytical applications. Isopropamide iodide is a long-acting quaternary anticholinergic agent. Isopropamide iodide is used in peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
    Isopropamide iodide (Standard)
  • HY-W201842A
    Octamylamine sulfamate
    		Inhibitor
    Octamylamine sulfamate is an anticholinergic and antispasmodic agent.
    Octamylamine sulfamate
  • HY-105182AR
    Xanomeline tartrate (Standard)
    		Agonist
    Xanomeline (tartrate) (Standard) is the analytical standard of Xanomeline (tartrate). This product is intended for research and analytical applications. Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia.
    Xanomeline tartrate (Standard)
  • HY-B1621AR
    Cyclopentolate hydrochloride (Standard)
    		Antagonist
    Cyclopentolate (hydrochloride) (Standard) is the analytical standard of Cyclopentolate (hydrochloride). This product is intended for research and analytical applications. Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.
    Cyclopentolate hydrochloride (Standard)
  • HY-137311A
    (S)-Albuterol
    		Activator
    (S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle.
    (S)-Albuterol
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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