2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00230A
    CDD0102 hydrochloride
    		Agonist
    CDD0102 Hydrochloride is a potent M1 Muscarinic receptor agonist.
    CDD0102 hydrochloride
  • HY-W037331
    4,4-Difluorobenzhydrol
    		Antagonist 98.21%
    4,4-Difluorobenzhydrol is a precursor of a mAChR antagonist, and its derivative 4,4-Difluorobenzhydrol Carbamate can selectively target the M1 subtype.
    4,4-Difluorobenzhydrol
  • HY-B0962AR
    Piperidolate (Standard)
    		Inhibitor
    Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. 0
    Piperidolate (Standard)
  • HY-W746075A
    (±)-Darifenacin N-Oxide
    		Control
    (±)-Darifenacin N-Oxide is the impurity of Darifenacin (HY-A0033). Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9.
    (±)-Darifenacin N-Oxide
  • HY-149703
    M1/M4 muscarinic agonist 2
    M1/M4 muscarinic antagonist 2 (compound 40) is a selective M1 and M4 agonist with IC5019 nM and 42 nM, respectively.
    M1/M4 muscarinic agonist 2
  • HY-A0024R
    Tolterodine (Standard)
    		Antagonist
    Tolterodine (Standard) is the analytical standard of Tolterodine. This product is intended for research and analytical applications. 0
    Tolterodine (Standard)
  • HY-122491
    Dimethyl-W84 dibromide
    		Modulator
    Dimethyl-W84 (dibromide) modulates M2 muscarinic acetylcholine receptors. Dimethyl-W84 (dibromide) can be used in nervous system related research.
    Dimethyl-W84 dibromide
  • HY-125700
    Baogongteng A
    		Agonist
    Baogongteng A ((-)-Bao Gong Teng A) is an optically active tropane alkaloid with hypotensive and miotic activity, and can be isolated from the Chinese herb Erycibe obtusifolia Benth. Baogongteng A is also a muscarinic agonist. Baogongteng A can be used for cardiovascular and glaucoma research.
    Baogongteng A
  • HY-101586
    Alvameline
    		Antagonist
    Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.
    Alvameline
  • HY-127022A
    Anisodine hydrobromide
    		Inhibitor
    Anisodine (Daturamine) hydrobromide is a neuroprotective compound that reduces exacerbated M1, M2, M4, and M5 receptor expression in brain tissues under hypoxia/reoxygenation conditions. Anisodine hydrobromide inhibits calcium ion influx and reactive oxygen species (ROS)levels. Anisodine hydrobromide leads to decreased aspartate levels during hypoxia.
    Anisodine hydrobromide
  • HY-W708197
    Tolterodine dimer
    		Control
    Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.
    Tolterodine dimer
  • HY-B0954R
    Oxyphencyclimine hydrochloride (Standard)
    		Antagonist
    Oxyphencyclimine (hydrochloride) (Standard) is the analytical standard of Oxyphencyclimine (hydrochloride). This product is intended for research and analytical applications. A new tertiary amine, Oxyphencyclimine hydrochloride，has been investigated for its effects on the peripheral parasympathetic system.
    Oxyphencyclimine hydrochloride (Standard)
  • HY-126184
    Revatropate
    		Antagonist
    Revatropate is an antimuscarinic compound. Revatropate has a much greater inhibitory effect on M1 and M3 receptors than on the M2 subtype. Revatropate is used in the study of urge urinary incontinence and functional bowel disorders.
    Revatropate
  • HY-101086R
    Acetylcholine iodide (Standard)
    Acetylcholine (iodide) (Standard) is the analytical standard of Acetylcholine (iodide). This product is intended for research and analytical applications. Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system.
    Acetylcholine iodide (Standard)
  • HY-14541A
    Olanzapine hydrochloride
    		Antagonist
    Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine hydrochloride is an atypical antipsychotic.
    Olanzapine hydrochloride
  • HY-119333
    NNC 11-1607
    		Agonist
    NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia.
    NNC 11-1607
  • HY-134081
    Desiodomethyl 4-DAMP
    		Antagonist
    Desiodomethyl 4-DAMP is a muscarinic receptor antagonist.
    Desiodomethyl 4-DAMP
  • HY-12980R
    Batefenterol (Standard)
    		Antagonist
    Batefenterol (Standard) is the analytical standard of Batefenterol. This product is intended for research and analytical applications. Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
    Batefenterol (Standard)
  • HY-121773
    Metoquizine
    Metoquizine is an anticholinergic agent.
    Metoquizine
  • HY-149504
    3-Hydroxy darifenacin
    		Antagonist
    3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
    3-Hydroxy darifenacin
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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