2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

PDF 3.54 MB

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0241S1
    Ipratropium-d7 bromide
    		Antagonist
    Ipratropium-d7 (bromide)eis the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.
    Ipratropium-d<sub>7</sub> bromide
  • HY-120842
    RLH-033
    RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [3H](+)-pentazocine with a Ki of 50 pM.
    RLH-033
  • HY-17037R
    Pirenzepine dihydrochloride (Standard)
    		Antagonist
    Pirenzepine (dihydrochloride) (Standard) is the analytical standard of Pirenzepine (dihydrochloride). This product is intended for research and analytical applications. Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells.
    Pirenzepine dihydrochloride (Standard)
  • HY-126862
    AQ-RA 721
    		Antagonist
    AQ-RA 721 is a muscarinic receptor antagonist with differential affinity for the m4 and M2 sites, which can be used to characterize muscarinic receptor subtypes. Other muscarinic receptor antagonists have differential affinity for the M1 (rat cerebral cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (receptor expressed in Chinese hamster ovary cells transfected with CHO), and guinea pig uterine smooth muscle at the muscarinic binding site.
    AQ-RA 721
  • HY-106432
    Sabcomeline
    		Agonist
    Sabcomeline (SB-202026) is a potent and functionally selective muscarinic M1 receptor partial agonist that improve cognition. Sabcomeline can be used for Alzheimer's disease research.
    Sabcomeline
  • HY-116459
    trans-Cevimeline hydrochloride
    		Agonist
    Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease.
    trans-Cevimeline hydrochloride
  • HY-A0083R
    Methacholine chloride (Standard)
    		Agonist
    Methacholine (chloride) (Standard) is the analytical standard of Methacholine (chloride). This product is intended for research and analytical applications. Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
    Methacholine chloride (Standard)
  • HY-B1006R
    Pilocarpine nitrate (Standard)
    		Agonist
    Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
    Pilocarpine nitrate (Standard)
  • HY-134971
    AE9C90CB
    		Antagonist
    AE9C90CB, muscarinic receptor antagonist, has greater affinity for M3 muscarinic receptors with pKi of 9.90 and was 20-fold more selective for M3 than for M2 muscarinic receptors.
    AE9C90CB
  • HY-14541S1
    Olanzapine-d4
    		Antagonist
    Olanzapine-d4 (LY170053-d4) is deuterium-labeled Olanzapine (HY-14541).
    Olanzapine-d<sub>4</sub>
  • HY-B0241R
    Ipratropium bromide (Standard)
    		Antagonist
    Ipratropium (bromide) (Standard) is the analytical standard of Ipratropium (bromide). This product is intended for research and analytical applications. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with IC50s of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide relaxes smooth muscle, can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.
    Ipratropium bromide (Standard)
  • HY-76772R
    Cevimeline hydrochloride hemihydrate (Standard)
    		Agonist
    Cevimeline (hydrochloride hemihydrate) (Standard) is the analytical standard of Cevimeline (hydrochloride hemihydrate). This product is intended for research and analytical applications. Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB).
    Cevimeline hydrochloride hemihydrate (Standard)
  • HY-U00230A
    CDD0102 hydrochloride
    		Agonist
    CDD0102 Hydrochloride is a potent M1 Muscarinic receptor agonist.
    CDD0102 hydrochloride
  • HY-W037331
    4,4-Difluorobenzhydrol
    		Antagonist 98.21%
    4,4-Difluorobenzhydrol is a precursor of a mAChR antagonist, and its derivative 4,4-Difluorobenzhydrol Carbamate can selectively target the M1 subtype.
    4,4-Difluorobenzhydrol
  • HY-B0962AR
    Piperidolate (Standard)
    		Inhibitor
    Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. 0
    Piperidolate (Standard)
  • HY-W746075A
    (±)-Darifenacin N-Oxide
    		Control
    (±)-Darifenacin N-Oxide is the impurity of Darifenacin (HY-A0033). Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9.
    (±)-Darifenacin N-Oxide
  • HY-149703
    M1/M4 muscarinic agonist 2
    M1/M4 muscarinic antagonist 2 (compound 40) is a selective M1 and M4 agonist with IC5019 nM and 42 nM, respectively.
    M1/M4 muscarinic agonist 2
  • HY-A0024R
    Tolterodine (Standard)
    		Antagonist
    Tolterodine (Standard) is the analytical standard of Tolterodine. This product is intended for research and analytical applications. 0
    Tolterodine (Standard)
  • HY-122491
    Dimethyl-W84 dibromide
    		Modulator
    Dimethyl-W84 (dibromide) modulates M2 muscarinic acetylcholine receptors. Dimethyl-W84 (dibromide) can be used in nervous system related research.
    Dimethyl-W84 dibromide
  • HY-125700
    Baogongteng A
    		Agonist
    Baogongteng A ((-)-Bao Gong Teng A) is an optically active tropane alkaloid with hypotensive and miotic activity, and can be isolated from the Chinese herb Erycibe obtusifolia Benth. Baogongteng A is also a muscarinic agonist. Baogongteng A can be used for cardiovascular and glaucoma research.
    Baogongteng A
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.