2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR

mAChR

Muscarinic acetylcholine receptor

mAChR

Related Products

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mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR Isoform Specific Products:

mAChR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121404
    Muscarine
    		Agonist
    Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system.
    Muscarine
  • HY-N0340R
    Scopolamine butylbromide (Standard)
    		Antagonist
    Scopolamine butylbromide (Standard) is the analytical standard of Scopolamine butylbromide. This product is intended for research and analytical applications. 0
    Scopolamine butylbromide (Standard)
  • HY-16171R
    Diphenmanil methylsulfate (Standard)
    		Antagonist
    Diphenmanil (methylsulfate) (Standard) is the analytical standard of Diphenmanil (methylsulfate). This product is intended for research and analytical applications. 0
    Diphenmanil methylsulfate (Standard)
  • HY-122761
    Quifenadine
    		Antagonist
    Quifenadine (Compound 3a), the hydroxyl-(diphenyl)methyl quinuclidine derivative, is a M3 receptor antagonist with an IC50 value > 1000 nM. Quifenadine can be used for the research of neurological disease.
    Quifenadine
  • HY-W748582
    Clozapine N-oxide-d8
    Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
    Clozapine N-oxide-d<sub>8</sub>
  • HY-W354753
    Homatropine hydrochloride
    		Inhibitor
    Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs.
    Homatropine hydrochloride
  • HY-120081AR
    Metixene hydrochloride hydrate (Standard)
    		Antagonist
    Metixene (hydrochloride hydrate) (Standard) is the analytical standard of Metixene (hydrochloride hydrate). This product is intended for research and analytical applications. Metixene (Piperidine) hydrochloride hydrate is an anticholinergic and antiparkinsonian agent. Metixene hydrochloride hydrate potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used for the research of parkinsonian.
    Metixene hydrochloride hydrate (Standard)
  • HY-167933
    (Rac)-Sabcomeline hydrochloride
    		Inhibitor
    (Rac)-Sabcomeline ((Rac)-SB-202026) hydrochloride serves as an M1 receptor agonist, making it a valuable tool for research into Alzheimer's disease.
    (Rac)-Sabcomeline hydrochloride
  • HY-106949
    Tazomeline
    		Agonist
    Tazomeline is a selective M1 muscarinic receptor agonist. Tazomeline inhibits twitch height in rabbit vas deferens(IC50= 0.001 nM). Tazomeline can be used for research of neuropsychiatric disorders.
    Tazomeline
  • HY-119082
    (E/Z)-VU0029767
    		Modulator
    (E/Z)-VU0029767 is an allosteric enhancer of M1 muscarinic receptors with the activity to modulate M1 receptor activity. (E/Z)-VU0029767 can enhance M1 receptor activity by increasing agonist affinity, but exhibits different properties from other compounds under different experimental conditions, such as effects on mutant M1 receptors and effects on downstream signaling pathways.
    (E/Z)-VU0029767
  • HY-105771
    Parapenzolate bromide
    		Antagonist
    Parapenzolate bromide, an antispasmodic, is an orally active mAChR antagonist. Parapenzolate bromide is an anticholinergic agent.
    Parapenzolate bromide
  • HY-162491
    JR-6
    		Agonist
    JR-6 is a Gi/o pathway biased and muscarinic M2 selective partial agonist.
    JR-6
  • HY-B0321R
    Tropicamide (Standard)
    		Antagonist
    Tropicamide (Standard) is the analytical standard of Tropicamide. This product is intended for research and analytical applications. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops.
    Tropicamide (Standard)
  • HY-76570S2
    (Rac)-5-hydroxymethyl Tolterodine-d5
    		Antagonist
    (Rac)-5-hydroxymethyl Tolterodine-d5 ((Rac)-Desfesoterodine-d5; (Rac)-PNU-200577-d5) is deuterium-labeled (Rac)-5-Hydroxymethyl Tolterodine (HY-76570).
    (Rac)-5-hydroxymethyl Tolterodine-d5
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride
    		Agonist 99.74%
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist.
    N-Desmethylclozapine-d<sub>8</sub> hydrochloride
  • HY-120322
    MK-0969
    		Antagonist
    MK-0969 is a M3 antagonist. MK-0969 can be used for research about chronic obstructive pulmonary disease and urinary incontinence.
    MK-0969
  • HY-109006
    Ilmetropium iodide
    		Inhibitor
    Ilmetropium iodide is an anticholinergic agent. Ilmetropium iodide selectively blocks M-cholinergic receptors of bronchial muscle, reduces or prevents bronchoconstrictor response associated with both cholinergic stimulation, as well as the impact of the factors that provoke bronchospasm. Strength and selectivity of ilmetropium iodide action substantially exceeds Atropine sulfate (HY-B1205A) and Ipratropium bromide (HY-B0241).
    Ilmetropium iodide
  • HY-116586A
    (Rac)-AF710B
    		Agonist
    (Rac)-AF710B is the racemate of AF710B (HY-116586). AF710B is a highly potent and selective allosteric M1 muscarinic and σ1 receptor agonist. AF710B can be used for the research of Alzheimer’s disease.
    (Rac)-AF710B
  • HY-B0520AR
    Benztropine mesylate (Standard)
    		Inhibitor
    Benztropine (mesylate) (Standard) is the analytical standard of Benztropine (mesylate). This product is intended for research and analytical applications. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.
    Benztropine mesylate (Standard)
  • HY-17037S
    Pirenzepine-d8
    Pirenzepine-d8 is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.
    Pirenzepine-d<sub>8</sub>
Cat. No. Product Name / Synonyms Application Reactivity
mAChR Isoform Comparison

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