Kallikrein

Kallikrein Related Products (31):

By Effects:	Substrates (2) Inhibitors (23) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-16735

Avoralstat	Inhibitor	≥98.0%
Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research.

HY-P99110

Lanadelumab	Inhibitor	99.90%
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K_i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema.

HY-132830

Sebetralstat	Inhibitor	99.58%
Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases.

HY-148949

Kallikrein 5-IN-2		98.96%
Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC₅₀=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching.

HY-109127

Berotralstat	Inhibitor	99.70%
Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.

HY-P991676

Eflumenibep alfa	Inhibitor
Eflumenibep alfa is a Kallikrein 5 inhibitor with anti-inflammatory activity. Eflumenibep alfa is a fusion protein that combines human SPINK2 with the human IgG1 Fc fragment at the C-terminus.

HY-150519

FXIa-IN-11	Inhibitor
FXIa-IN-11 (Example 26) is an inhibitor of factor XIa and plasma kallikrein. FXIa-IN-11 can be studied in research on inflammatory diseases.

HY-129047E

Trypsin, porcine pancreas (Cell culture grade)	Activator
Trypsin, porcine pancreas (Cell culture grade) is a serine protease enzyme that hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin, porcine pancreas (Cell culture grade) has an excellent protein digestibility for α-lactalbumin and β-casein. Trypsin, porcine pancreas (Cell culture grade) activates kallikrein and regulates the blood pressure. Trypsin, Human Pancreas is an activator for PAR, thereby regulating cellular inflammatory and immune responses.

HY-P4245

D-Pro-Phe-Arg-Chloromethylketone	Inhibitor	99.24%
D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation.

HY-108814A

Ecallantide TFA	Inhibitor	98.94%
Ecallantide (DX-88) TFA is a specific recombinant plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide may be used to prevent acute attacks of angioedema.

HY-109127A

Berotralstat dihydrochloride	Inhibitor	98.49%
Berotralstat dihydrochloride (BCX7353 dihydrochloride) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.

HY-123133

PKSI-527	Inhibitor	98.08%
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system.

HY-P0237A

KKI-5 TFA		98.74%
KKI-5 (TFA) is a specific inhibitor of tissue kallikrein. KKI-5 (TFA) can attenuate breast cancer cell invasion.

HY-145568

Feniralstat	Inhibitor	99.87%
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM).

HY-153115

Plasma kallikrein-IN-4	Inhibitor	98.61%
Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC₅₀ of 0.016 μM against human plasma kallikrein.

HY-114150D

D-Val-Leu-Arg-pNA acetate		99.75%
D-Val-Leu-Arg-pNA (acetate) is the acetate form of D-Pro-Phe-Arg-p-nitroanilide (pNa). D-Pro-Phe-Arg-p-nitroanilide (pNa) is the substrate for kallikrein and can be used to assay the activity of kallikrein.

HY-122543

PPACK II diTFA	Inhibitor
PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor.

HY-126378

LSP-249	Inhibitor	99.05%
LSP-249 (example 35), extracted from patent WO2016011209A1, is a plasma kallikrein inhibitor under the study for angioedema, with an EC₅₀ less than 100 nM in cell.

HY-139888

Plasma kallikrein-IN-1	Inhibitor
Plasma kallikrein-IN-1 is a PKK inhibitor with an IC₅₀ value of 0.5 nM.

HY-108814

Ecallantide	Inhibitor
Ecallantide (DX-88) is a specific plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema.

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