2. Signaling Pathways
  3. Others
  4. Isotope-Labeled Compounds

Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Related Products (9979):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-51424S
    PLX-4720-d7
    PLX-4720-d7 is the deuterium labeled PLX-4720. PLX-4720 is a potent and selective inhibitor of?B-RafV600E?with?an IC50?of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
    PLX-4720-d<sub>7</sub>
  • HY-13756S2
    Tacrolimus-d3
    Tacrolimus-d3 (FK506-d3) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
    Tacrolimus-d<sub>3</sub>
  • HY-W422491S
    (R)-2-phenyl-2-((R)-piperidin-2-yl)acetic acid-d5 trifluoroacetate
    (R)-2-phenyl-2-((R)-piperidin-2-yl)acetic acid-d5 (D-threo-Ritalinic Acid-d5) TFA is deuterium-labeled (R)-2-phenyl-2-((R)-piperidin-2-yl)acetic acid (HY-W422491).
    (R)-2-phenyl-2-((R)-piperidin-2-yl)acetic acid-d<sub>5</sub> trifluoroacetate
  • HY-B0130S1
    Perindopril-d5
    Perindopril-d5 (S-9490-d5) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension.
    Perindopril-d<sub>5</sub>
  • HY-W754842
    Saxagliptin-13C,d2-1 hydrochloride
    Saxagliptin-13C,d2-1 (BMS-477118-13C,d2) hydrochloride is 13C and deuterium labeled Saxagliptin (hydrochloride).
    Saxagliptin-<sup>13</sup>C,d<sub>2</sub>-1 hydrochloride
  • HY-B0760S1
    Fenofibric acid-13C8
    Fenofibric acid-13C8 (FNF acid-13C8) is 13C labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
    Fenofibric acid-<sup>13</sup>C<sub>8</sub>
  • HY-15027S3
    5-Aminosalicylic acid-d3 disodium
    5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
    5-Aminosalicylic acid-d<sub>3</sub> disodium
  • HY-W015780S1
    1,4-Dimethoxybenzene-d4
    1,4-Dimethoxybenzene-d4 is the deuterium labeled 1,4-Dimethoxybenzene (HY-W015780).1,4-Dimethoxybenzene is an endogenous metabolite.
    1,4-Dimethoxybenzene-d<sub>4</sub>
  • HY-13599S2
    Cladribine-15N
    Cladribine-15N (2-Chloro-2′-deoxyadenosine-15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis.
    Cladribine-<sup>15</sup>N
  • HY-176145S
    N-Benzyl-2-iodo-N-(prop-2-yn-1-yl)acetamide-13C
    N-Benzyl-2-iodo-N-(prop-2-yn-1-yl)acetamide-13C is the 13C-labeled N-Benzyl-2-iodo-N-(prop-2-yn-1-yl)acetamide.
    N-Benzyl-2-iodo-N-(prop-2-yn-1-yl)acetamide-<sup>13</sup>C
  • HY-146708S
    ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-15N4 sodium
    ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-15N4 (sodium) is a 15N-labeled ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (so
    ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-<sup>15</sup>N<sub>4</sub> sodium
  • HY-19344S2
    Lifitegrast-d4-1
    Lifitegrast-d4-1 is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
    Lifitegrast-d<sub>4</sub>-1
  • HY-117853S
    Atreleuton-d4
    Atreleuton-d4 (ABT-761-d4; VIA-2291-d4) is deuterium-labeled Atreleuton (HY-117853).
    Atreleuton-d<sub>4</sub>
  • HY-15531S1
    Venetoclax-d6
    Venetoclax-d6 (ABT-199-d6) is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.
    Venetoclax-d<sub>6</sub>
  • HY-15258S1
    Lesinurad-d4
    Lesinurad-d4 (RDEA594-d4) is deuterium labeled Lesinurad. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
    Lesinurad-d<sub>4</sub>
  • HY-137030S
    2-Benzotriazol-2-yl-4,6-bis(1-methyl-1-phenylethyl)phenol-d4 (UV-234-d4)
    2-Benzotriazol-2-yl-4,6-bis(1-methyl-1-phenylethyl)phenol-d4 (UV-234-d4) (UV-234-d4) is deuterium labeled UV-234.
    2-Benzotriazol-2-yl-4,6-bis(1-methyl-1-phenylethyl)phenol-d<sub>4</sub> (UV-234-d<sub>4</sub>)
  • HY-W278362S
    2-Acetamidobenzamide-d3
    2-Acetamidobenzamide-d3 is the deuterium labeled 2-Acetamidobenzamide.
    2-Acetamidobenzamide-d<sub>3</sub>
  • HY-N10004S
    Fructose-proline-13C6
    Fructose-proline-13C6 is 13C labeled Fructose-proline.
    Fructose-proline-<sup>13</sup>C<sub>6</sub>
  • HY-W715351S
    1,2,4,5,7,8-Hexachloro naphthalene-13C10
    1,2,4,5,7,8-Hexachloro naphthalene-13C10 is 13C labeled 1,2,4,5,7,8-Hexachloronaphthalene.
    1,2,4,5,7,8-Hexachloro naphthalene-<sup>13</sup>C<sub>10</sub>
  • HY-W653912A
    Leucovorin-d4 (calcium hydrate), >90%
    Leucovorin-d4 (Leucovorin-d4) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
    Leucovorin-d<sub>4</sub> (calcium hydrate), >90%