2. Signaling Pathways
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  4. Galectin

Galectin

Galectin

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Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans. Galectins are usually classified into three groups based on their structure: (i) prototypical galectins (galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), characterized by a single CRD, which can act as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), with a single CRD and a large amino-terminal domain that facilitates the formation of oligomers; (iii) the tandem repeat galectins, with two CRDs that are linked through a small peptide domain; this group includes Gal4, Gal6, Gal8, Gal9, and Gal12. Recently, Galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies.

Galectin Isoform Specific Products:

Galectin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157822
    Galectin-8-IN-2
    		Inhibitor
    Galectin-8-IN-2 (Compound 10) is a galectin-8N inhibitor.
    Galectin-8-IN-2
  • HY-157824
    6Lac[6]Met
    		Inhibitor
    6Lac[6]Met is a galectin 4 inhibitor with an IC50 value 5 μM.
    6Lac[6]Met
  • HY-170510
    GB2095
    		Inhibitor
    GB2095 is a selective, orally active inhibitor for galectin-3 with Kd of 36 nM and 0.35 μM for human galectin-3 and mouse galectin-3. GB2095 exhibits antitumor efficacy in mouse models.
    GB2095
  • HY-139831
    Galectin-8-IN-1
    Galectin-8-IN-1 is a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a Kd of 48 μM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins.
    Galectin-8-IN-1
  • HY-162561
    GB1908
    		Inhibitor
    GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer.
    GB1908
  • HY-157820
    Galectin-4-IN-2
    		Inhibitor
    Galectin-4-IN-2 (compound 12) is an inhibitor of galectin 4C with a galectin dissociation constant of 1.6 mM.
    Galectin-4-IN-2
  • HY-147865
    Apoptosis inducer 8
    		Inhibitor
    Apoptosis inducer 8 (Compound 7c) is a galectin-1 (gal-1) mediated apoptosis-inducing agent against global major leading lung cancer burden. Apoptosis inducer 8 significantly reduced the gal-1 protein level. Apoptosis inducer 8 is also a PET imaging agent.
    Apoptosis inducer 8
  • HY-163407
    Galectin-3-IN-4
    		Inhibitor
    Galectin-3-IN-4 (compound 5) is a carboxamide analog. Galectin-3-IN-4 is a potent, selective, and orally bioavailable inhibitor of human and mouse galectin-3, with IC50 values of 21 and 167 nM for hGal-3 and mGal-3, respectively. Galectin-3-IN-4 has IC50 values of 1580 and 2750 nM for hGal-1 and hGal-9, respectively.
    Galectin-3-IN-4
  • HY-144313
    Galectin-3-IN-2
    		Inhibitor
    Galectin-3-IN-2 (Compound 9) is a potent multivalent inhibitor of galectin-3 (Gal-3; IC50=8.3 μM). Galectin-3 participates in many cancer-related metabolic processes.
    Galectin-3-IN-2
  • HY-173235
    Galectin-3-IN-6
    		Inhibitor
    Galectin-3-IN-6 (Compound 12) is an orally active inhibitor of galectin-3 (Gal-3), with an IC50 value of 12 nM and a Kd value of 13 nM for Gal-3. In a mouse model of acute liver injury and fibrosis induced by CCl4, Galectin-3-IN-6 can significantly reduce the levels of fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, showing significant anti-fibrotic activity. Galectin-3-IN-6 can be used in the research of fibrotic diseases, cancer, and cardiovascular diseases.
    Galectin-3-IN-6
  • HY-147041A
    (2S)-Selvigaltin
    		Inhibitor
    (2S)-Selvigaltin is the S-enantiomer of Selvigaltin (HY-147041). Selvigaltin is an orally active galectin-3 (Gal-3) inhibitor.
    (2S)-Selvigaltin
  • HY-123708
    SNAP 398299
    		Antagonist
    SNAP 398299 is a Gal3 receptor antagonist with potential anxiolytic and antidepressant effects. SNAP 398299 can partially reverse the neuropeptide Galanin-induced inhibition of dorsal raphe cell firing and the Galanin-induced hyperpolarizing current.
    SNAP 398299
  • HY-146809
    Galectin-3 antagonist 2
    Galectin-3 is a β Galactoside specific carbohydrate recognition protein (lectin) has the ability to promote the migration of B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and withstand drug research.
    Galectin-3 antagonist 2
  • HY-163405
    Galectin-3-IN-3
    		Inhibitor
    Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.
    Galectin-3-IN-3
  • HY-W340234
    4,5-Dibromo-2-pyrrolic acid
    4,5-Dibromo-2-pyrrolic acid (compound 2) is an immunosuppressive compound. 4,5-Dibromo-2-pyrrolic acid suppresses the proliferative response of splenocytes to suboptimal concentrations of the mitogen, concanavalin A (Con A).
    4,5-Dibromo-2-pyrrolic acid
  • HY-162789
    Galectin-3-IN-5
    		Inhibitor
    Galectin-3-IN-5 (Compound 20) is an orally active inhibitor of galectin-3 (Gal-3), with an IC50 value of 9.2 nM against hGal-3.
    Galectin-3-IN-5
  • HY-163082
    GB1490
    		Inhibitor
    GB1490 is an orally active galectin inhibitor with Kd values of 0.4 μM and 2.7 μM for galectin-1 and galectin-3, respectively.
    GB1490
  • HY-163900
    Galectin-8N-IN-2
    		Inhibitor
    Galectin-8N-IN-2 (compound 2) is a potent and selective Galectin-8N inhibitor with a Ki value of 74 μM.
    Galectin-8N-IN-2
Cat. No. Product Name / Synonyms Application Reactivity
Galectin Isoform Comparison

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