2. Immunology/Inflammation
  3. Galectin
  4. GB1908

GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer.

For research use only. We do not sell to patients.

GB1908

GB1908 Chemical Structure

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Based on 1 publication(s) in Google Scholar

GB1908 Related Antibodies

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Description

GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer[1].

IC50 & Target[1]

Galectin-1

57 nM (Ki, Human galectin-1)

Galectin-1

72 nM (Ki, Mouse galectin-1)

Galectin-3

6000 nM (Ki, Human galectin-3)

Galectin-3

4200 nM (Ki, Mouse galectin-3)

In Vitro

GB1908 (0.1-10 μM; 16 h) inhibits galectin-1-induced apoptosis in Jurkat cells (IC50 of 850 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GB1908 Related Antibodies

Apoptosis Analysis[1]

Cell Line: Jurkat cells treatment with galectin-1
Concentration: 0.1-10 μM
Incubation Time: 16 h
Result: Inhibited galectin-1-induced apoptosis.
In Vivo

GB1908 (compound 5d; 30 mg/kg; po; twice a day; for 21 days) reduces the growth of primary lung tumor LL/2 in a syngeneic mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6N mice injected with LL/2 (LLC1) Lewis lung carcinoma cells[1]
Dosage: 30 mg/kg (PEG300/Solutol HS15/Tween 20 solution (85/15/1% v/v))
Administration: po; twice a day; for 21 days
Result: Significantly inhibited tumor growth.
Molecular Weight

505.40

Formula

C18H18Cl2N4O5S2
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=CC(S[C@H]2O[C@H](CO)[C@H](O)[C@H](N3C=C(C4=CSC(O)=N4)N=N3)[C@H]2OC)=CC=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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GB1908 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GB1908GB 1908GB-1908Galectinorally activegalectin-1 inhibitorlung cancerInhibitorinhibitorinhibit

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