2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Fat Mass and Obesity-associated Protein (FTO)
  5. Fat Mass and Obesity-associated Protein (FTO) Degrader

Fat Mass and Obesity-associated Protein (FTO) Degrader

Fat Mass and Obesity-associated Protein (FTO) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-175885
    PROTAC FTO degrader 1
    		Degrader
    PROTAC FTO degrader 1 is a Fat Mass and Obesity-associated Protein (FTO) PROTAC degrader. PROTAC FTO degrader 1 selectively degrades FTO depending on VHL E3 ligase and ubiquitin-proteasome system. PROTAC FTO degrader 1 can increase m6A modifications on mRNAs associated with ribosome biogenesis and promote their YTHDF2-mediated decay. PROTAC FTO degrader 1 can inhibit cancer cells proliferation and induce apoptosis. PROTAC FTO degrader 1 can be used for the research of cancer, such as acute myeloid leukemia (AML). (Structure Note: Pink: FTO ligand (HY-175886); Blue: VHL ligand (HY-112078); Black: linker (HY-W002042); VHL ligand-Linker: (HY-139218))