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  4. Drug Isomer

Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer Related Products (217):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W007880A
    (R)-D2PM hydrochloride
    (R)-D2PM ((R)-Diphenylprolinol) hydrochloride is an isomer of the psychoactive substance D2PM and a pyrrolidine analog.
    (R)-D2PM hydrochloride
  • HY-109854
    (S)-Lisofylline
    		99.89%
    (S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline.
    (S)-Lisofylline
  • HY-162683A
    (R)-PHA533533
    (R)-PHA533533 is an inactive enantiomer (S)-PHA533533 (active enantiomer) (HY-162683). (S)-PHA533533 is a CDK2 inhibitor with antitumor activity.
    (R)-PHA533533
  • HY-123382
    GSK-1482160 (isomer)
    GSK-1482160 isomer is the isomer of GSK-1482160 (HY-19888). GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).
    GSK-1482160 (isomer)
  • HY-76542AR
    5,6-trans-Vitamin D2 (Standard)
    5,6-trans-Vitamin D2 (Standard) is the analytical standard of 5,6-trans-Vitamin D2. This product is intended for research and analytical applications. 5,6-trans-Vitamin D2 is the isomer of Vitamin D2[1].
    5,6-trans-Vitamin D2 (Standard)
  • HY-10121D
    rel-Asenapine hydrochloride
    rel-Asenapine (rel-Org 5222) hydrochloride is a relative configuration of Asenapine hydrochloride (HY-16567). Asenapine (Org 5222) hydrochloride, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine hydrochloride can be used in the research of schizophrenia and bipolar disorder.
    rel-Asenapine hydrochloride
  • HY-18500
    (βS)-β-Hydroxy-L-histidine hydrochloride
    (βS)-β-Hydroxy-L-histidine hydrochloride is a stereoisomer of β-hydroxyhistidine.
    (βS)-β-Hydroxy-L-histidine hydrochloride
  • HY-129764A
    (17E)-Prostaglandin F3α
    (17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity.
    (17E)-Prostaglandin F3α
  • HY-15743A
    (R)-Birabresib
    		99.94%
    (R)-Birabresib is the isomer of Birabresib (HY-15743), and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.
    (R)-Birabresib
  • HY-135597
    N-Acetyl-5-methyl-L-tryptophan
    		98.39%
    N-Acetyl-5-methyl-L-tryptophan is a N-Acetyl-L-tryptophan analog.
    N-Acetyl-5-methyl-L-tryptophan
  • HY-161474
    Antiproliferative agent-50
    Antiproliferative agent-50 (Compd VIII-a) is an inhibitor of myeloma cell proliferation and may be used to inhibit multiple myeloma.
    Antiproliferative agent-50
  • HY-141551B
    (R)-GNE-274
    (R)-GNE-274 is a enantiomer of GNE-274. GNE-274 is a non-degrader that is structurally related to GDC-0927 (estrogen receptor degrader).
    (R)-GNE-274
  • HY-149053A
    (S)-OY-101
    (S)-OY-101 is an isomer of OY-101 (HY-149053).
    (S)-OY-101
  • HY-W699829
    (3R,5R)-Rosuvastatin Lactone-d6
    (3R,5R)-Rosuvastatin Lactone-d6 is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
    (3R,5R)-Rosuvastatin Lactone-d<sub>6</sub>
  • HY-107608A
    5(S),12(S)-Leukotriene B4
    5(S),12(S)-Leukotriene B4 (5(S),12(S)-LTB4; 5(S),12(S)-DiHETE) is a stereochemical isomer of LTB4 (HY-107608).
    5(S),12(S)-Leukotriene B4
  • HY-124281A
    9(S)-PAHSA
    9(S)-PAHSA is a S-enantiomer of 9-PAHSA. 9-PAHSA is an orally available anti-inflammatory lipid that lowers blood sugar and reduces inflammation.
    9(S)-PAHSA
  • HY-N7801
    (±)5-HEPE
    (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
    (±)5-HEPE
  • HY-115408
    9(R)-HETE
    9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    9(R)-HETE
  • HY-W747563
    11-trans Leukotriene D4
    11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
    11-trans Leukotriene D4
  • HY-B0317DR
    (R)-Amlodipine (Standard)
    (R)-Amlodipine (Standard) is the analytical standard of (R)-Amlodipine. This product is intended for research and analytical applications. (R)-Amlodipine is the R-Enantiomer of Amlodipine (HY-B0317 )
    (R)-Amlodipine (Standard)