2. Signaling Pathways
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  4. Drug Isomer

Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer Related Products (190):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114395A
    (R)-NVS-ZP7-4
    		98.80%
    (R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel agentgable node in the Notch pathway.
    (R)-NVS-ZP7-4
  • HY-160144S2
    (rac)-Lomedeucitinib
    		98.11%
    (rac)-Lomedeucitinib ((rac)-BMS-986322) is the racemate of Lomedeucitinib. Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC50=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus.
    (rac)-Lomedeucitinib
  • HY-13250B
    Silvestrol aglycone (enantiomer)
    		99.10%
    Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol.
    Silvestrol aglycone (enantiomer)
  • HY-100181B
    (R)-PF-04991532
    		99.87%
    (R)-PF-04991532 is the R-enantiomer of PF-04991532 (HY-100181). PF-04991532 is a potent, hepatoselective glucokinase activator.
    (R)-PF-04991532
  • HY-125135
    (-)-β-Peltatin
    		99.45%
    (-)-β-Peltatin is an organic heterotetracyclic compound with antitumor activity and phytometabolite effects that are functionally related to α-peltatin.
    (-)-β-Peltatin
  • HY-N7199
    (Rac)-Hydnocarpin
    		Control
    (Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells.
    (Rac)-Hydnocarpin
  • HY-145388B
    AU-16235
    		Control 99.52%
    AU-16235 is an inactive epimer of AU-15330. AU-16235 has no effect on cancer cell survival and growth
    AU-16235
  • HY-107842
    (Z)-JIB-04
    		Control 99.42%
    (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis.
    (Z)-JIB-04
  • HY-113972A
    (E/Z)-Methyl mycophenolate
    (E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.
    (E/Z)-Methyl mycophenolate
  • HY-123905A
    LIN28 inhibitor LI71 enantiomer
    		99.68%
    LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.
    LIN28 inhibitor LI71 enantiomer
  • HY-15532B
    SCH900776 (S-isomer)
    		99.28%
    SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM.
    SCH900776 (S-isomer)
  • HY-108418A
    (R)-PI3Kδ-IN-15
    		99.52%
    (R)-PI3Kδ-IN-15 is the R-enantiomer of PI3Kδ-IN-15 (HY-108418).
    (R)-PI3Kδ-IN-15
  • HY-139534A
    (S)-ARI-1
    		Control 99.80%
    (S)-ARI-1 is an S-enantiomer of ARI-1. ARI-1 is a ROR1 inhibitor and apoptosis inducer, used in NSCLC research.
    (S)-ARI-1
  • HY-77111
    cis-INCB3344
    cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
    cis-INCB3344
  • HY-100013B1
    (1S,2S)-2-PCCA hydrochloride
    		99.65%
    (1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.
    (1S,2S)-2-PCCA hydrochloride
  • HY-131408
    L-Allooctopine
    		99.60%
    L-Allooctopine is a competitive inhibitor of D-octopine.
    L-Allooctopine
  • HY-136453A
    CR-1-30-B
    		99.92%
    CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
    CR-1-30-B
  • HY-132809B
    (Rac)-Baxdrostat
    		Inhibitor 99.03%
    (Rac)-Baxdrostat is the isomer of Baxdrostat (HY-132809), and can be used as an experimental control. Baxdrostat is a aldosterone synthase inhibitor.
    (Rac)-Baxdrostat
  • HY-W112166
    (E/Z)-4,4'-Dicyanostilbene
    		98.34%
    (E/Z)-4,4'-Dicyanostilbene is the isomer of 4,4'-Dicyanostilbene (HY-W112166A), and can be used as an experimental control. 4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC50 of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).
    (E/Z)-4,4'-Dicyanostilbene
  • HY-12567A
    (R)-ML375
    		98.19%
    (R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 (HY-12567). (R)-ML375 is devoid of M5 mAChR activity (hM5, IC50>30 μM).
    (R)-ML375