2. Signaling Pathways
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  4. Drug Isomer

Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer Related Products (209):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110155A
    (Rac)-LM11A-31 dihydrochloride
    		≥98.0%
    (Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist.
    (Rac)-LM11A-31 dihydrochloride
  • HY-100540C
    Golgicide A-1
    		Control 99.94%
    Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction.
    Golgicide A-1
  • HY-112101
    Prohydrojasmon racemate
    		≥98.0%
    Prohydrojasmon racemate (n-Propyl dihydrojasmonate) is the racemate of Prohydrojasmon. Prohydrojasmon is a synthesized plant growth regulator.
    Prohydrojasmon racemate
  • HY-W342979
    Petroselaidic acid
    		≥98.0%
    Petroselaidic acid is a trans fatty acid and the trans isomer of Petroselinic acid (HY-113362). Petroselaidic acid can be found in dairy products such as cow's milk and goat's milk.
    Petroselaidic acid
  • HY-104065A
    (Rac)-Pyrotinib
    		99.29%
    (Rac)-Pyrotinib ((Rac)-SHR-1258) is the racemic form of Pyrotinib (HY-104065). Pyrotinib is a potent and selective dual EGFR/HER2 receptor inhibitor.
    (Rac)-Pyrotinib
  • HY-114395A
    (R)-NVS-ZP7-4
    		98.80%
    (R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel agentgable node in the Notch pathway.
    (R)-NVS-ZP7-4
  • HY-111191A
    (R)-ONO-2952
    		99.97%
    (R)-ONO-2952 is a R-enantiomer of ONO-2952. ONO-2952 is a potent, selective and orally active TSPO antagonist with Kis of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes.
    (R)-ONO-2952
  • HY-160144S2
    (rac)-Lomedeucitinib
    		98.11%
    (rac)-Lomedeucitinib ((rac)-BMS-986322) is the racemate of Lomedeucitinib. Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC50=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus.
    (rac)-Lomedeucitinib
  • HY-13250B
    Silvestrol aglycone (enantiomer)
    		99.10%
    Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol.
    Silvestrol aglycone (enantiomer)
  • HY-100181B
    (R)-PF-04991532
    		99.87%
    (R)-PF-04991532 is the R-enantiomer of PF-04991532 (HY-100181). PF-04991532 is a potent, hepatoselective glucokinase activator.
    (R)-PF-04991532
  • HY-125135
    (-)-β-Peltatin
    		99.45%
    (-)-β-Peltatin is an organic heterotetracyclic compound with antitumor activity and phytometabolite effects that are functionally related to α-peltatin.
    (-)-β-Peltatin
  • HY-N7199
    (Rac)-Hydnocarpin
    		Control
    (Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells.
    (Rac)-Hydnocarpin
  • HY-145388B
    AU-16235
    		Control 99.54%
    AU-16235 is an inactive epimer of AU-15330. AU-16235 has no effect on cancer cell survival and growth
    AU-16235
  • HY-107842
    (Z)-JIB-04
    		Control 99.42%
    (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis.
    (Z)-JIB-04
  • HY-113972A
    (E/Z)-Methyl mycophenolate
    (E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.
    (E/Z)-Methyl mycophenolate
  • HY-123905A
    LIN28 inhibitor LI71 enantiomer
    		99.68%
    LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.
    LIN28 inhibitor LI71 enantiomer
  • HY-129770A
    D-Methionine sulfoxide hydrochloride
    		99.82%
    D-methionine sulfoxide hydrochloride is the D-isomer of Methionine sulfoxide hydrochloride. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins, which is easily oxidized during the course of storage or processing.
    D-Methionine sulfoxide hydrochloride
  • HY-108418A
    (R)-PI3Kδ-IN-15
    		99.52%
    (R)-PI3Kδ-IN-15 is the R-enantiomer of PI3Kδ-IN-15 (HY-108418).
    (R)-PI3Kδ-IN-15
  • HY-139534A
    (S)-ARI-1
    		Control 99.80%
    (S)-ARI-1 is an S-enantiomer of ARI-1. ARI-1 is a ROR1 inhibitor and apoptosis inducer, used in NSCLC research.
    (S)-ARI-1
  • HY-77111
    cis-INCB3344
    cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
    cis-INCB3344