2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (1479):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12424
    Zotarolimus
    		≥98.0%
    Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.
    Zotarolimus
  • HY-N6821
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
    		99.58%
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid is a glucoside derivative of ascorbic acid, shows anti-cancer activity after enzymatic hydrolysis to ascorbic acid.
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium
    		≥98.0%
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-128775
    JHU395
    		99.69%
    JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
    JHU395
  • HY-111179
    ML261
    		99.80%
    ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation.
    ML261
  • HY-13769A
    TPT-260 Dihydrochloride
    		≥98.0%
    TPT-260 Dihydrochloride (NSC55712) is a thiourea derivative.
    TPT-260 Dihydrochloride
  • HY-B2212
    Dibenzoyl Thiamine
    		99.83%
    Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.
    Dibenzoyl Thiamine
  • HY-W017764
    7,8-Dihydro-2,5(1H,6H)-quinolinedione
    7,8-Dihydro-2,5(1H,6H)-quinolinedione (compound SF32) is a positive inotropic agent.
    7,8-Dihydro-2,5(1H,6H)-quinolinedione
  • HY-B1442
    Acetylleucine
    		99.38%
    Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus.
    Acetylleucine
  • HY-W002304
    (R)-5-Oxopyrrolidine-2-carboxylic acid
    		≥98.0%
    (R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease.
    (R)-5-Oxopyrrolidine-2-carboxylic acid
  • HY-B1785
    5-Sulfosalicylic acid
    		98.74%
    5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity. 5-Sulfosalicylic acid has antioxidant activities.
    5-Sulfosalicylic acid
  • HY-122273
    Pyrithiamine hydrobromide
    Pyrithiamine hydrobromide is a thiamine metabolic inhibitor that can act as a substrate for thiamine pyrophosphokinase. Pyrithiamine hydrobromide can be used in the research of nervous system diseases .
    Pyrithiamine hydrobromide
  • HY-W004290S
    Methyl heptadecanoate-d33
    		99.04%
    Methyl heptadecanoate-d33 is the deuterium labeled Methyl heptadecanoate (HY-W004290). Methyl heptadecanoate (C17:0 methyl ester) is the methyl ester derivative of heptadecanoic acid (HY-W004284). Methyl heptadecanoate is used as an internal standard for quantitative calibration of fatty acids in GC-MS analysis.
    Methyl heptadecanoate-d<sub>33</sub>
  • HY-158998
    ALKBH1-IN-2
    		99.16%
    ALKBH1-IN-2 (Compound 16) is a derivative of ALKBH1-IN-1 (HY-163385). ALKBH1-IN-2 is an ALKBH1 inhibitor. ALKBH1-IN-2 can modulate the 6mA levels.
    ALKBH1-IN-2
  • HY-146748
    Sorbicillin
    		99.69%
    Sorbicillin, a sorbicillinoid analogue, acts as a potent anti-inflammation agent.
    Sorbicillin
  • HY-126247B
    (R)-BI-2852
    (R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
    (R)-BI-2852
  • HY-Y1777
    2-Phenylacetophenone
    		99.96%
    2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization.
    2-Phenylacetophenone
  • HY-131116
    Dihydrojasmonic acid
    		99.26%
    Dihydrojasmonic acid is a plant growth regulator.
    Dihydrojasmonic acid
  • HY-122365
    Inositol nicotinate
    		98.05%
    Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters.
    Inositol nicotinate
  • HY-139167
    7-Hydroxywarfarin
    		99.39%
    7-Hydroxywarfarin is a Warfarin analog with anticoagulant activity.
    7-Hydroxywarfarin