2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (1528):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12424
    Zotarolimus
    		≥98.0%
    Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.
    Zotarolimus
  • HY-79602
    p-Toluenesulfonamide
    		99.98%
    p-Toluenesulfonamide is an intermediate and plasticizer. p-Toluenesulfonamide is also the main degradation product of the disinfectant Chloramine-T (HY-B0959) in water. p-Toluenesulfonamide facilitates the localization of fluorescent probes to the endoplasmic reticulum.
    p-Toluenesulfonamide
  • HY-N6880
    Rabdosiin
    		99.55%
    Rabdosiin ((+)-Rabdosiin) is a Caffeic acid (HY-N0172) tetramer. Rabdosiin can be isolated from Macrotomia euchroma.
    Rabdosiin
  • HY-N0097A
    9-β-D-Arabinofuranosylguanine
    		99.77%
    9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease.
    9-β-D-Arabinofuranosylguanine
  • HY-13769A
    TPT-260 Dihydrochloride
    		98.0%
    TPT-260 Dihydrochloride (NSC55712) is a thiourea derivative.
    TPT-260 Dihydrochloride
  • HY-128775
    JHU395
    		99.69%
    JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
    JHU395
  • HY-136506
    NUC-7738
    NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer.
    NUC-7738
  • HY-111179
    ML261
    		99.80%
    ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation.
    ML261
  • HY-N2108
    7-Ethylcamptothecin
    		99.58%
    7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research.
    7-Ethylcamptothecin
  • HY-N6821
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
    		99.81%
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid is a glucoside derivative of ascorbic acid, shows anti-cancer activity after enzymatic hydrolysis to ascorbic acid.
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
  • HY-141490
    Beta-D-Glucopyranosyl nitromethane
    		99.94%
    Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane.
    Beta-D-Glucopyranosyl nitromethane
  • HY-158998
    ALKBH1-IN-2
    		99.16%
    ALKBH1-IN-2 (Compound 16) is a derivative of ALKBH1-IN-1 (HY-163385). ALKBH1-IN-2 is an ALKBH1 inhibitor. ALKBH1-IN-2 can modulate the 6mA levels.
    ALKBH1-IN-2
  • HY-W017764
    7,8-Dihydro-2,5(1H,6H)-quinolinedione
    7,8-Dihydro-2,5(1H,6H)-quinolinedione (compound SF32) is a positive inotropic agent.
    7,8-Dihydro-2,5(1H,6H)-quinolinedione
  • HY-B1442
    Acetylleucine
    		99.38%
    Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus.
    Acetylleucine
  • HY-B1785
    5-Sulfosalicylic acid
    		98.74%
    5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity. 5-Sulfosalicylic acid has antioxidant activities.
    5-Sulfosalicylic acid
  • HY-B2212
    Dibenzoyl Thiamine
    		99.83%
    Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.
    Dibenzoyl Thiamine
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium
    		≥98.0%
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-W004290S
    Methyl heptadecanoate-d33
    		99.04%
    Methyl heptadecanoate-d33 is the deuterium labeled Methyl heptadecanoate (HY-W004290). Methyl heptadecanoate (C17:0 methyl ester) is the methyl ester derivative of heptadecanoic acid (HY-W004284). Methyl heptadecanoate is used as an internal standard for quantitative calibration of fatty acids in GC-MS analysis.
    Methyl heptadecanoate-d<sub>33</sub>
  • HY-W002304
    (R)-5-Oxopyrrolidine-2-carboxylic acid
    		≥98.0%
    (R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease.
    (R)-5-Oxopyrrolidine-2-carboxylic acid
  • HY-W088929
    H-Glu(OtBu)-NH2 hydrochloride
    		98.0%
    H-Glu(OtBu)-NH2 (hydrochloride) is an active compound.
    H-Glu(OtBu)-NH2 hydrochloride