2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (1384):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13250
    Silvestrol aglycone
    		99.84%
    Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity.
    Silvestrol aglycone
  • HY-B0079
    Sugammadex sodium
    		≥98.0%
    Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex sodium shows nephroprotective effect in ischemia-reperfusion injury.
    Sugammadex sodium
  • HY-W011053
    Neotame
    		98.00%
    Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells.
    Neotame
  • HY-113468A
    3-O-Methyldopa
    		99.16%
    3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease.
    3-O-Methyldopa
  • HY-160429
    PSAR18-COOH
    		99.86%
    PSAR18-COOH is a derivative of PSAR extracted from patent WO2009064913A1. PSAR is a highly hydrophilic, biodegradable, non-immunogenic and water-soluble polymer that has been employed in several delivery systems for drugs or diagnostics.
    PSAR18-COOH
  • HY-W016321
    N-Benzylaniline
    		99.88%
    N-Benzylaniline (N-Phenylbenzylamine) is an N-alkyl­ated derivative of aniline.
    N-Benzylaniline
  • HY-79139
    Pteroic acid
    		98.03%
    Pteroic acid is an active compound.
    Pteroic acid
  • HY-N0097A
    9-β-D-Arabinofuranosylguanine
    		99.24%
    9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease.
    9-β-D-Arabinofuranosylguanine
  • HY-B2102
    Oxyphenisatine
    		98.12%
    Oxyphenisatine (Oxyphenisatin) is a laxative. Oxyphenisatin acetate is the pro-agent of oxyphenisatin with anticancer activity.
    Oxyphenisatine
  • HY-41982
    D-Glucuronic acid lactone
    		≥98.0%
    D-Glucuronic acid lactone (D-Glucurono-6,3-lactone) is an endogenous metabolite, which is a glucuronic acid derivative. D-Glucuronic acid lactone can be used as starting regents in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, requirement for the preparation of 1-O-acyl glucuronide of the anti-inflammatory agent ML-3000 (HY-B1452), synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides. D-Glucuronic acid lactone is promising for research of reversible cerebral vasoconstriction syndrome (RCVS).
    D-Glucuronic acid lactone
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium
    		≥98.0%
    2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-129430
    N-Methylprotoporphyrin IX
    		≥99.0%
    N-Methylprotoporphyrin IX is a potent inhibitor of ferrochelatase enzyme.
    N-Methylprotoporphyrin IX
  • HY-W005627
    Linoleyl alcohol
    		99.84%
    Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol.
    Linoleyl alcohol
  • HY-W111581
    Copper(II) diethyldithiocarbamate
    Copper(II) diethyldithiocarbamate has anticancer activity. Copper(II) diethyldithiocarbamate can be synthesized from monovalent copper-cysteamine and disulfiram.
    Copper(II) diethyldithiocarbamate
  • HY-136506
    NUC-7738
    NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer.
    NUC-7738
  • HY-153182
    GBT1118
    		99.97%
    GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia.
    GBT1118
  • HY-B2212
    Dibenzoyl Thiamine
    		99.83%
    Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.
    Dibenzoyl Thiamine
  • HY-12424
    Zotarolimus
    		≥98.0%
    Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.
    Zotarolimus
  • HY-128775
    JHU395
    		99.88%
    JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
    JHU395
  • HY-107859
    Tris(2-chloroethyl) phosphate
    Tris(2-chloroethyl) phosphate is an active compound.
    Tris(2-chloroethyl) phosphate