2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carboxylesterase (CES)

Carboxylesterase (CES)

Carboxylesterase; Carboxylic-ester Hydrolase

Cboxylesterases (CES) are serine hydrolases belonging to the superfamily of proteins with α/β hydrolase fold. Cboxylesterases are widely distributed in many tissues including liver, intestine, lung and kidney. Cboxylesterases catalyze the ester cleavage of a large number of structurally diverse ester- or amide-containing substrates into the corresponding alcohol and carboxylic acid. Actually, Cboxylesterases can hydrolyze ester, thioester, amide, and carbamate linkages in a wide variety of endo- and xenobiotic compounds, thus playing key roles in both endobiotic metabolism, and in activation and/or detoxification of xenobiotics. In humans, three Cboxylesterases have been identified, namely human carboxylesterase 1 (CES1), CES2, and CES3. Among them, CES1 and CES2 are two widely studied isoenzymes involved in xenobiotic metabolism. Cboxylesterases play an important role in the metabolism of various xenobiotics including ester drugs and environmental toxicants, and also participate in lipid homeostasis[1].

Carboxylesterase (CES) Isoform Specific Products:

Carboxylesterase (CES) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P4611
    Z-Pro-Ala
    Z-Pro-Ala is an acid carboxypeptidase. Z-Pro-Ala can be isolated from grains and leaves of wheat, Triticum aestivum L.
    Z-Pro-Ala
  • HY-N0235R
    Bakuchiol (Standard)
    		Inhibitor
    Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory, antibacterial, antitumor therapies, as well as drug metabolism regulation.
    Bakuchiol (Standard)
  • HY-N1377R
    Nevadensin (Standard)
    		Inhibitor
    Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.
    Nevadensin (Standard)
  • HY-147331A
    Oseltamivir acid methyl ester hydrochloride
    		Inhibitor
    Oseltamivir acid methyl ester hydrochloride is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester hydrochloride is converted to oseltamivir acid by carboxylesterase 1 (CES1).
    Oseltamivir acid methyl ester hydrochloride
  • HY-162502
    WZU-13
    		Inhibitor
    WZU-13 is an inhibitor for Carboxylesterase (CES). WZU-13 inhibits 77% CES activity at a dose of 100 μM.
    WZU-13
  • HY-141834
    Carboxylesterase-IN-1
    Carboxylesterase-IN-1, a novel pesticide, exhibits inhibitory action on carboxylesterase at 50 μg/mL similar to the known inhibitor triphenyl phosphate.
    Carboxylesterase-IN-1
  • HY-129748
    SQ-24798
    		Inhibitor
    SQ-24,798 is a compound that inhibits carboxypeptidase B with high affinity and specificity. Its inhibitory effect may be achieved through the binding of the sulfhydryl group to the zinc ion of the enzyme and specific side chains.
    SQ-24798
  • HY-155755
    hCES2A-IN-1
    		Inhibitor
    hCES2A-IN-1 (compound 20w) is a potent hCES2A inhibitor, with an IC50 value of 1.6 nM. hCES2A-IN-1, a bysspectin A derivative, shows an approximately 1000-fold improvement over the lead compound bysspectin A.
    hCES2A-IN-1
  • HY-148360
    Notum pectinacetylesterase-1
    		Inhibitor
    Notum pectinacetylesterase-1 is a potent inhibitor of notum pectinacetylesterase. Notum pectinacetylesterase-1 can be used for the research of disorders affecting the bone.
    Notum pectinacetylesterase-1
Carboxylesterase (CES) Isoform Comparison

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