2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139744
    FPI-1465
    		Inhibitor
    FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively.
    FPI-1465
  • HY-19050
    BRL-42715
    		Inhibitor
    BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .
    BRL-42715
  • HY-B1825R
    Cefoxitin (Standard)
    Cefoxitin (Standard) is the analytical standard of Cefoxitin. This product is intended for research and analytical applications. Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria.
    Cefoxitin (Standard)
  • HY-143415
    Metallo-β-lactamase-IN-7
    		Inhibitor
    Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains.
    Metallo-β-lactamase-IN-7
  • HY-144262
    Metallo-β-lactamase-IN-4
    		Inhibitor
    Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively.
    Metallo-β-lactamase-IN-4
  • HY-B1484A
    Moxalactam
    		Inhibitor
    Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases.
    Moxalactam
  • HY-155283
    Zndm19
    		Inhibitor
    Zndm19 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor. Zndm19 can be used for the research of drug-resistant bacterial infections.
    Zndm19
  • HY-146637
    VIM-2-IN-1
    		Inhibitor
    VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC50 values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively.
    VIM-2-IN-1
  • HY-139751
    β-Lactamase-IN-4
    		Inhibitor
    β-Lactamase-IN-4 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections.
    β-Lactamase-IN-4
  • HY-143414
    Metallo-β-lactamase-IN-6
    		Inhibitor
    Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL.
    Metallo-β-lactamase-IN-6
  • HY-139746
    FPI-1602
    		Inhibitor
    FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp..
    FPI-1602
  • HY-172243
    Xeruborbactam isoboxil
    		Inhibitor
    Xeruborbactam isoboxil is a beta-lactamase inhibitor.
    Xeruborbactam isoboxil
  • HY-158375
    MBL-IN-4
    		Inhibitor
    MBL-IN-4 (compound 4b) is a MBL inhibitor with the IC50 of 4.81 and 33 μM against IMP-1 and NDM-1.
    MBL-IN-4
  • HY-108288R
    Sulbactam pivoxil (Standard)
    		Inhibitor
    Sulbactam pivoxil (Standard) (Pivsulbactam (Standard)) is the analytical standard of Sulbactam pivoxil (HY-108288). This product is intended for research and analytical applications. Sulbactam pivoxil (Pivsulbactam) is a prodrug of Sulbactam (HY-B0334) with oral activity. Sulbactam is a β-lactamase inhibitor with antibacterial activity. Sulbactam pivoxil is better absorbed than Sulbactam and results in higher serum levels after oral administration.
    Sulbactam pivoxil (Standard)
  • HY-B0466BR
    Cloxacillin sodium (Standard)
    		Inhibitor
    Cloxacillin (sodium) (Standard) is the analytical standard of Cloxacillin (sodium). This product is intended for research and analytical applications. Cloxacillin sodium is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin sodium can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin sodium (Standard)
  • HY-119945
    Brobactam
    		Inhibitor
    Brobactam is a potent synthetic wide spectrum β-lactamase inhibitor. Brobactam has antibacterial activity.
    Brobactam
  • HY-138247
    β-Lactamase-IN-2
    		Inhibitor 98.59%
    β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects.
    β-Lactamase-IN-2
  • HY-B0466R
    Cloxacillin sodium monohydrate (Standard)
    		Inhibitor
    Cloxacillin (sodium monohydrate) (Standard) is the analytical standard of Cloxacillin (sodium monohydrate). This product is intended for research and analytical applications. Cloxacillin sodium monohydrate is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin sodium monohydrate can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin sodium monohydrate (Standard)
  • HY-139699
    GT-055
    		Inhibitor
    GT-055 (LCB18-055) is a novel broad-spectrum β-lactamase inhibitor.
    GT-055
  • HY-144229
    trans-Cephalosporin
    		Inhibitor
    Trans substituted cephalosporin is an effective NDM-1 inhibitor，with an IC50 value of 0.13 μM.
    trans-Cephalosporin
Beta-lactamase Isoform Comparison

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