2. Signaling Pathways
  3. Apoptosis
  4. ASK1
  5. ASK1 Degrader

ASK1 Degrader

ASK1 Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-174858
    dASK1-VHL
    		Degrader
    dASK1-VHL is an orally active PROTAC degrader targeting ASK1. dASK1-VHL can effectively bind VHL and promote the selective degradation of ASK1. dASK1-VHL effectively reduces ASK1 protein levels, inhibits the activation of p38 MAPK, and reduces liver lipid content. dASK1-VHL provides new ideas for the study of Metabolic dysfunction-associated steatohepatitis (MASH) (Pink: ASK1 ligand 1 (HY-174860); Blue: E3 ligand (S,R,S)-AHPC (HY-125845); Black: Linker, (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH (HY-174861).
  • HY-174860
    ASK1 ligand 1
    		Degrader
    ASK1 ligand 1 is a binding ligand for ASK1 and can be used to synthesize PROTACs such as dASK1-VHL (HY-174858)[1].
  • HY-174862
    dASK1
    		Degrader
    dASK1 is a selective and cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1). dASK1 forms a stable ternary complex with ASK1, facilitating ASK1 rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 demonstrates potent ASK1 degradation. dASK1 can be used for the research of steatohepatitis. (Structure Note: Pink: ASK1 ligand (HY-174860); Blue: CRBN ligand (HY-10984); Black: linker; E3-linker (HY-174863))