2. Signaling Pathways
  3. Apoptosis
  4. ASK1
  5. ASK1 Activator

ASK1 Activator

ASK1 Activator (1):

Cat. No. Product Name Effect Purity
  • HY-179033
    Nur77 antagonist 2
    		Activator
    Nur77 antagonist 2 (Compound 12b) is an orally active Nur77 antagonist with a KD value of 0.42 μM. Nur77 antagonist 2 exhibits proliferative activity on liver cancer cells. Nur77 antagonist 2 stabilizes Nur77 by inhibiting its ubiquitin-proteasomal degradation, leading to Nur77-dependent apoptosis via the ASK1-JNK/p38 pathway. Nur77 antagonist 2 inhibits tumor growth in the HCCLM3 xenograft model. Nur77 antagonist 2 can be used for the study of hepatocellular carcinoma (HCC).