2. Signaling Pathways
  3. GPCR/G Protein
  4. Arrestin
  5. Arrestin-3/β-Arrestin 2 Isoform
  6. Arrestin-3/β-Arrestin 2 Inhibitor

Arrestin-3/β-Arrestin 2 Inhibitor

Arrestin-3/β-Arrestin 2 Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-119706
    Barbadin
    		Inhibitor 98.93%
    Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis.
  • HY-175366
    DOR agonist 3
    		Inhibitor
    DOR agonist 3 (Compound 10) is a δ-opioid receptor (DOR)-selective positive allosteric modulator. DOR agonist 3 enhances G protein signaling while reducing β-arrestin2 recruitment. DOR agonist 3 is promising for research of chronic pain and depression.
  • HY-175306
    GPR183 inverse agonist-1
    		Inhibitor
    GPR183 inverse agonist-1 (Compound 78) is a GPR183 inverse agonist. GPR183 inverse agonist-1 inhibits the GPR183-mediated Gi activation and β-arrestin2 recruitment, and blocks PBMC migration. GPR183 inverse agonist-1 can be used for inflammatory, autoimmune and neoplastic disorders research.