Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1619):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W009534

Boc-N-Me-Leu-OH
Boc-N-Me-Leu-OH is a leucine derivative.

HY-W092107

Dibenzyl aspartate 4-methylbenzenesulfonate
Dibenzyl aspartate 4-methylbenzenesulfonate is an aspartic acid derivative.

HY-41318

N-Z-L-proline methyl ester		99.88%
N-Z-L-proline methyl ester is a proline derivative.

HY-W037441

N-Boc-L-3,5-difluorophenylalanine		99.79%
N-Boc-L-3,5-difluorophenylalanine is a phenylalanine derivative.

HY-W101495

Boc-Leu-OH hydrate
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity.

HY-76317

Z-DL-Pro-OH		98.04%
Z-DL-Pro-OH (N-Cbz-DL-proline) is a proline derivative, can be used for the synthesis of agents or other compounds.

HY-W048681

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(4-(tert-butoxy)-4-oxobutyl)-L-cysteine		98.69%
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(4-(tert-butoxy)-4-oxobutyl)-L-cysteine is a cysteine derivative.

HY-P4106A

Tat-GluR23Y, scrambled TFA		99.43%
Tat-GluR23Y, scrambled TFA is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD).

HY-W012707

(S)-2-Amino-2,3-dimethylbutanoic acid		99.90%
(S)-2-Amino-2,3-dimethylbutanoic acid is a valine derivative.

HY-W013906

Boc-DL-Phg-OH		99.97%
Boc-DL-Phg-OH is a Glycine (HY-Y0966) derivative.

HY-77151

Ethyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate
Ethyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate is an alanine derivative.

HY-W013291A

H-D-Asp(OtBu)-OtBu·HCl
H-D-Asp(OtBu)-OtBu·HCl is the isomer of H-Asp(OtBu)-OtBu.HCl (HY-W013291), and can be used as an experimental control. H-Asp(OtBu)-OtBu.HCl is an aspartic acid derivative.

HY-Y0029

Boc-D-Asp-OBzl		99.80%
Boc-D-Asp-OBzl is an aspartic acid derivative.

HY-145512

N-(α-Linolenoyl) tyrosine		99.3%
N-(α-Linolenoyl) tyrosine (NLT) is atyrosine derivatives.

HY-P2399

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH		99.74%
Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

HY-W008464

H-Thr(Me)-OH		≥98.0%
H-Thr(Me)-OH is a threonine derivative.

HY-P5169A

LVGRQLEEFL (mouse) TFA		98.20%
LVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death.

HY-W098273

Methyl 2-amino-3-chloropropanoate hydrochloride
Methyl 2-amino-3-chloropropanoate hydrochloride is a serine derivative.

HY-I0749A

(S)-Methyl 2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetate		99.31%
(S)-Methyl 2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetate is a phenylalanine derivative.

HY-W009840

H-Asp(ome)-OMe HCl
H-Asp(ome)-OMe HCl is an aspartic acid derivative.

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