2. Signaling Pathways
  3. Stem Cell/Wnt
  4. YAP
  5. YAP Agonist

YAP Agonist

YAP Isoform Comparison

YAP Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-175247
    DDO-4033
    		Agonist
    DDO-4033 is a SPOP inhibitor (IC50 = 16.9 μM, Kd = 15.1 μM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research.