2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. VD/VDR

VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

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Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161778
    ZG-126
    		Agonist
    ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization.
    ZG-126
  • HY-10002S1
    Calcitriol-d3
    Calcitriol-d3 is the deuterium labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    Calcitriol-d<sub>3</sub>
  • HY-19911
    Pefcalcitol
    Pefcalcitol is a new antipsoriatic anteagent candidates having 16-en-22-oxa-vitamin D3 structures.
    Pefcalcitol
  • HY-19380
    Ro-65-2299
    		Agonist
    Ro-65-2299 is an orally active retiferol Vitamin D analogue and a potential VDR agonist (ED50 = 180 nM). Ro-65-2299 can induce thickening of the epidermis and exhibits antipsoriatic effect in hairless mice (ED50 = 7.5 mg/kg). Ro-65-2299 can be used for the researches of inflammation and immunology, such as psoriasis.
    Ro-65-2299
  • HY-119586
    LG190119
    		Modulator
    J1075 is a selective Schistosoma mansoni HDAC8 modulator (with decreased affinity for human HDAC8). J1075 can induce apoptosis (Apoptosis) and death in schistosome cells. J1075 holds research value in the field of anti-parasitic agents.
    LG190119
  • HY-A0020R
    Eldecalcitol (Standard)
    		Activator
    Eldecalcitol (Standard) is the analytical standard of Eldecalcitol. This product is intended for research and analytical applications. Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1.
    Eldecalcitol (Standard)
  • HY-32350R
    Ercalcitriol (Standard)
    		Activator
    Ercalcitriol (Standard) is the analytical standard of Ercalcitriol. This product is intended for research and analytical applications. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
    Ercalcitriol (Standard)
  • HY-32337R
    Tacalcitol (Standard)
    		Activator
    Tacalcitol (Standard) is the analytical standard of Tacalcitol. This product is intended for research and analytical applications. Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases.
    Tacalcitol (Standard)
  • HY-B1014R
    Acenocoumarol (Standard)
    		Antagonist
    Acenocoumarol (Standard) is the analytical standard of Acenocoumarol. This product is intended for research and analytical applications. Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.
    Acenocoumarol (Standard)
  • HY-B0325R
    Phenindione (Standard)
    		Antagonist
    Phenindione (Standard) is the analytical standard of Phenindione. This product is intended for research and analytical applications. 0
    Phenindione (Standard)
  • HY-32349R
    Ercalcidiol (Standard)
    		Modulator
    Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
    Ercalcidiol (Standard)
  • HY-10003R
    Alfacalcidol (Standard)
    		Activator
    Alfacalcidol (Standard) is the analytical standard of Alfacalcidol. This product is intended for research and analytical applications. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis.
    Alfacalcidol (Standard)
  • HY-32348S1
    Doxercalciferol-d6
    		Activator
    Doxercalciferol-d6 (1.alpha.-Hydroxyvitamin D2-d6) is deuterium labeled Doxercalciferol. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.
    Doxercalciferol-d<sub>6</sub>
  • HY-13292R
    Impurity B of Calcitriol (Standard)
    		Activator
    Impurity B of Calcitriol (Standard) is the analytical standard of Impurity B of Calcitriol. This product is intended for research and analytical applications.
    Impurity B of Calcitriol (Standard)
  • HY-32351AR
    Calcifediol monohydrate (Standard)
    Calcifediol monohydrate (Standard) is the analytical standard of Calcifediol (monohydrate). This product is intended for research and analytical applications. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol monohydrate (Standard)
  • HY-W754025
    Pre-vitamin D3 decanoate
    Pre-vitamin D3 decanoate is a derivative of vitamin D3 that can be converted into the active form of vitamin D in the body. Pre-vitamin D3 decanoate is first converted to 25-hydroxyvitamin D3 in the liver and then further converted to 1,25-dihydroxyvitamin D3 in the kidneys. During preparation, vitamin D3 may react with the triglycerides in the formulation to form ester compounds, and this esterification affects the stability and bioavailability of vitamin D3. Pre-vitamin D3 decanoate can be used in the study of certain diseases associated with vitamin D, such as osteoporosis, autoimmune diseases, and certain cancers.
    Pre-vitamin D3 decanoate
  • HY-15327
    1alpha, 25-Dihydroxy VD2-d6
    		Activator 99%
    1alpha, 25-Dihydroxy VD2-d66 is a deuterated form of vitamin D.
    1alpha, 25-Dihydroxy VD2-d<sub>6</sub>
  • HY-B0918R
    Chlorindione (Standard)
    Chlorindione (Standard) is the analytical standard of Chlorindione. This product is intended for research and analytical applications. Chlorindione (Chlophenadione) is a potent anticoagulant. Chlorindione also is a vitamin K1 antagonist.
    Chlorindione (Standard)
  • HY-W013200
    Coumachlor
    		Antagonist
    Coumachlor is an orally active antieoagulant agent. Coumachlor is a vitamin K antagonist.
    Coumachlor
  • HY-B1014S
    Acenocoumarol-d5
    		Antagonist
    Acenocoumarol-d5 is the deuterium labeled Acenocoumarol (HY-B1014). Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.
    Acenocoumarol-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity