2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. VD/VDR

VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

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Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N10508
    Calcitroic acid
    		Agonist
    Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity.
    Calcitroic acid
  • HY-32351R
    Calcifediol (Standard)
    Calcifediol (Standard) is the analytical standard of Calcifediol. This product is intended for research and analytical applications. Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol (Standard)
  • HY-77274
    Calcitriol Impurities D
    		Activator
    Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
    Calcitriol Impurities D
  • HY-13292
    Impurity B of Calcitriol
    		Activator 98.04%
    Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
    Impurity B of Calcitriol
  • HY-154825
    20-Hydroxyvitamin D3
    		≥98.0%
    20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D3. 20-Hydroxyvitamin D3 functions as a ligand for vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation, induces differentiation. 20-Hydroxyvitamin D3 can be used for inflammatory and autoimmune diseases study.
    20-Hydroxyvitamin D3
  • HY-15398R
    Vitamin D3 (Standard)
    		Activator
    Vitamin D3 (Standard) is the analytical standard of Vitamin D3. This product is intended for research and analytical applications. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
    Vitamin D3 (Standard)
  • HY-76542S
    Vitamin D2-d6
    		Activator
    Vitamin D2-d6 is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
    Vitamin D2-d<sub>6</sub>
  • HY-134493
    Butyrate-Vitamin D3
    		Chemical
    Butyrate-Vitamin D3 (Butyrate-Cholecalciferol) is a derivative of vitamin D3 in which a hydroxyl group in the vitamin D3 molecule is replaced by a butyric acid group. Butyrate-Vitamin D3 affects gene expression and cell function and has certain anti-inflammatory effects. Butyrate-Vitamin D3 can be used in the study of immune regulation, metabolic diseases and cancer.
    Butyrate-Vitamin D3
  • HY-15264
    MC 1046
    		Activator
    MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.
    MC 1046
  • HY-15398S4
    Vitamin D3-13C5
    		Activator
    Vitamin D3-13C5 is the 13C-labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
    Vitamin D3-<sup>13</sup>C<sub>5</sub>
  • HY-114310
    VDR agonist 1
    		Agonist
    VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2.
    VDR agonist 1
  • HY-10002B
    (1R,5Z)-Calcitriol
    		Control
    (1R,5Z)-Calcitriol ((1R,5Z)-1,25-Dihydroxyvitamin D3) is a Calcitriol (HY-10002) isomer. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    (1R,5Z)-Calcitriol
  • HY-B1014S1
    Acenocoumarol-d4
    		Antagonist
    Acenocoumarol-d4 is deuterium labeled Acenocoumarol (HY-B1014). Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.
    Acenocoumarol-d<sub>4</sub>
  • HY-A0245R
    Dihydrotachysterol (Standard)
    		Modulator
    1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.
    Dihydrotachysterol (Standard)
  • HY-50919R
    Paricalcitol (Standard)
    		Agonist
    Paricalcitol (Standard) is the analytical standard of Paricalcitol. This product is intended for research and analytical applications. Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
    Paricalcitol (Standard)
  • HY-149899
    VDR agonist 2
    		Agonist
    VDR agonist 2 (compound 16i) is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC). VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo.
    VDR agonist 2
  • HY-32351AS1
    Calcifediol-13C5 monohydrate
    Calcifediol-13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-<sup>13</sup>C<sub>5</sub> monohydrate
  • HY-170975
    UG-650
    		Ligand
    UG-650 is a non-Gemini analog of UVB1 that combines the structural features of UVB1 and MC 1288. UG-650 can bind to the vitamin D receptor (VDR) and inhibit the proliferation of MCF-7 cells and the migration of MC3T3-E1 cells.
    UG-650
  • HY-156868
    22-Hydroxyvitamin D3
    22-Hydroxyvitamin D3 a novel vitamin D analog, that displays no vitamin D agonist activity in the intestine or in bone.
    22-Hydroxyvitamin D3
  • HY-106561
    Tioclomarol
    		Antagonist
    Tioclomarol, a coumarin anticoagulant, is a vitamin K antagonist.
    Tioclomarol
Cat. No. Product Name / Synonyms Application Reactivity