ULK Inhibitor

ULK Inhibitors (22):

Cat. No.	Product Name	Effect	Purity

HY-16966

SBI-0206965	Inhibitor	99.92%
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC₅₀s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2.

HY-13018

MRT67307	Inhibitor	99.44%
MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC₅₀s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC₅₀s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.

HY-100006A

MRT68921 dihydrochloride	Inhibitor	99.67%
MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC₅₀ values of 2.9 nM and 1.1 nM, respectively.

HY-100006

MRT68921	Inhibitor	99.71%
MRT68921 is a potent inhibitor of ULK1 and ULK2, with IC₅₀ values of 2.9 nM and 1.1 nM, respectively.

HY-114490

ULK-101	Inhibitor	99.91%
ULK-101 is a potent and selective ULK1 inhibitor, with IC₅₀ values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress.

HY-160699

DCC-3116	Inhibitor	99.25%
DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can inhibit autophagy in lung cancer cells by inhibiting KRAS^G12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects.

HY-137742

SBP-7455	Inhibitor	98.01%
SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC₅₀s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research.

HY-137506

XST-14	Inhibitor	99.26%
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC₅₀ of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.

HY-115570

GW406108X	Inhibitor	≥98.0%
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC₅₀ of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.

HY-143466

ULK1-IN-2	Inhibitor	99.09%
ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC₅₀ of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC (Non-small cell lung cancer).

HY-148065

FMF-06-098-1	Inhibitor	98.77%
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 (Pink: target protein ligand (HY-169396); Blue: VHL ligand (HY-112078); Black: Linker (HY-124380)).

HY-RS15451

ULK1 Human Pre-designed siRNA Set A	Inhibitor
ULK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-13018A

MRT67307 hydrochloride	Inhibitor
MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC₅₀s of 160 and 19 nM, respectively. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC₅₀s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells.

HY-RS15452

Ulk1 Mouse Pre-designed siRNA Set A	Inhibitor
Ulk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15454

ULK2 Human Pre-designed siRNA Set A	Inhibitor
ULK2 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-100006B

MRT68921 hydrochloride	Inhibitor
MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2, with IC₅₀ values of 2.9 nM and 1.1 nM, respectively.

HY-115570A

(Z/E)-GW406108X	Inhibitor
(Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM.

HY-13018B

MRT67307 dihydrochloride	Inhibitor
MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC₅₀s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC₅₀s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.

HY-161850

ULK1-IN-3	Inhibitor
ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines.

HY-RS15455

Ulk2 Mouse Pre-designed siRNA Set A	Inhibitor
Ulk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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