2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase
  5. Tyrosinase Inhibitor

Tyrosinase Inhibitor

Tyrosinase Inhibitors (227):

Cat. No. Product Name Effect Purity
  • HY-W552702
    Tyrosinase-IN-29
    		Inhibitor
    Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC50: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation.
  • HY-121174
    Alaternin
    		Inhibitor
    Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM.
  • HY-175349
    Tyrosinase-IN-43
    		Inhibitor
    Tyrosinase-IN-43 (Compound 12j) is a competitive Tyrosinase inhibitor with an IC50 of 10.49  μM for tyrosinase. Tyrosinase-IN-43 has significant antioxidant activity. Tyrosinase-IN-43 can be used for hyperpigmentation-related complications such as melasma, freckles, age spots and post-inflammatory hyperpigmentation research.
  • HY-175149A
    (+)-2-Fluorodeoxyarbutin
    		Inhibitor
    (+)-2-Fluorodeoxyarbutin is a fluorinated derivative of the tyrosinase inhibitor deoxyarbutin (HY-B1461).
  • HY-N3266R
    Methyl rosmarinate (Standard)
    		Inhibitor
    Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase.
  • HY-107369R
    4-Butylresorcinol (Standard)
    		Inhibitor
    4-Butylresorcinol (Standard) is the analytical standard of 4-Butylresorcinol. This product is intended for research and analytical applications. 4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.
  • HY-W050154R
    Kojic acid (Standard)
    		Inhibitor
    Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields.