Thrombin

Related Products

Thrombin is a Na⁺-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Thrombin Related Products (168)
Antibodies (9)

By Effects:	Substrates (6) Ligand (1) Inhibitors (121) Agonists (2) Antagonists (4) Activators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P0019

Z-Gly-Gly-Arg-AMC	Substrate	99.90%
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm).

HY-P2813

Hirudin	Inhibitor
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others.

HY-10787

Ximelagatran	Inhibitor	98.24%
Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcokinetics and pharmacodynamics.

HY-B0375A

Argatroban monohydrate	Inhibitor	99.98%
Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.

HY-10264B

Edoxaban tosylate monohydrate	Inhibitor	99.97%
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_is of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.

HY-100897

Sulodexide	Inhibitor
Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.

HY-17378

Dabigatran (ethyl ester)	Inhibitor	98.09%
Dabigatran ethyl ester is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.

HY-P4349A

Pyr-Arg-Thr-Lys-Arg-AMC TFA	Substrate	99.53%
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors.

HY-17567

Heparin	Inhibitor
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.

HY-18660

Ciraparantag	Inhibitor	≥98.0%
Ciraparantag (PER977) is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban.

HY-N6864

Isovanillic acid	Inhibitor	98.03%
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from Scrophularia ningpoensis, with anti-thrombotic activity.

HY-B0924

Anisindione	Inhibitor	98.07%
Anisindione is a synthetic anticoagulant. It inhibits the formation of active procoagulant factors II, VII, IX, and X.

HY-77521

Dabigatran ethyl ester hydrochloride	Inhibitor
Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC₅₀ value of 0.8 μM and a thrombin inhibitor.

HY-P1000

TRAP-14	Agonist	98.02%
TRAP-14 (SFLLRNPNDKYEPF) is a synthetic thrombin receptor agonist peptide.

HY-W004261

Nonadecanoic acid		≥98.0%
Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.

HY-P99725

Marstacimab	Activator
Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia.

HY-101054

NQ301		98.98%
NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC₅₀ of 10 mg/mL.

HY-10264S

Edoxaban-d₆	Inhibitor	99.6%
Edoxaban-d₆ is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment.

HY-163348

FXIIa-IN-4	Inhibitor	98.87%
FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC₅₀ of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant.

HY-101918

DS-1040 Tosylate	Inhibitor	99.26%
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Thrombin

Thrombin

Thrombin Related Products (168)

Antibodies (9)

Thrombin Related Products (168):