STING

Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS

STING

Related Products

Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.

STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.

STING Related Products (197)
Antibodies (13)

By Effects:	Controls (2) Inhibitors (39) Agonists (90) Degraders (10) Antagonists (3) Activators (35) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-137724A

C-di-IMP disodium	Agonist	99.9%
C-di-IMP disodium is a STING agonist. C-di-IMP disodium can be used in tumor research.

HY-163668

MK-2118	Agonist
MK-2118 is a GMP-synthesized STING agonist with the potential to inhibit advanced/metastatic solid tumors or lymphomas..

HY-148346A

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA	Agonist	98.30%
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer.

HY-B0984A

Fendiline	Agonist	99.41%
Fendiline, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC₅₀ of 17 µM). Fendiline is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline inhibits K-Ras plasma membrane localization (IC₅₀ of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10).

HY-152959

STING agonist-26	Agonist	99.56%
STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains.

HY-112921

diABZI STING agonist-1 (tautomerism)	Agonist	99.91%
diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921) (compound 3). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

HY-152034

STING-IN-5	Inhibitor	99.89%
STING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC₅₀ value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis.

HY-130115

IACS-8803	Agonist
IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.

HY-144168A

STING agonist-8 dihydrochloride	Agonist
STING agonist-8 dihydrochloride (compound 5-AB) is a potent STING agonist with an EC₅₀ of 27 nM in THP1-Dual KI-hSTING-R232 cells.

HY-113469B

Cyclic GMP (TBAOH)	Activator	99.07%
Cyclic GMP TBAOH is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP TBAOH can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP TBAOH may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of Cyclic GMP TBAOH, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP TBAOH can be used in the study of antiviral immunity and cardiovascular diseases.

HY-160226

ISD Control sodium
ISD (interferon stimulatory DNA) Control sodium is a non-immunostimulatory single-stranded oligonucleotide with the same sequence as ISD (HY-160225), its double-stranded counterpart. ISD Control can be used as a negative control for the CDS agonist ISD.

HY-122568

STING agonist-15	Agonist	≥99.0%
STING agonist-15 (Compound STING agonist-C11) Is a STING agonist. STING agonist-15 can be used for research of cancer and immune response.

HY-144168

STING agonist-8	Agonist
STING agonist-8 is a potent STING agonist with an EC₅₀ of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB).

HY-162465

BDW568	Agonist	99.4%
BDW568 is a STING agonist that can selectively activate the human STING^A230 allele. BDW568 can be used to activate STING^A230-engineered macrophages in macrophage-based immunotherapy.

HY-148346

STING agonist-20-Ala-amide-PEG2-C2-NH2	Agonist
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer.

HY-162133

MSA-2-Pt	Agonist
MSA-2-Pt is an orally active STING agonist that has good cell membrane permeability. MSA-2-Pt can induce cell death by Pt, which may release damaged DNA to activate the cGAS-STING pathway. Besides, MSA-2-Pt can activate the STING pathway directly by MSA-2. MSA-2-Pt can be used for the research of cancer.

HY-113469R

Cyclic GMP (Standard)	Activator
Cyclic GMP (Standard) is the analytical standard of Cyclic GMP. This product is intended for research and analytical applications. Cyclic GMP is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of Cyclic GMP, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases.

HY-152861

Dazostinag	Agonist
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs).

HY-141662

2',3'-cGAMP-C2-PPA	Agonist
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferon gene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases.

HY-111999B

E7766 disodium	Agonist
E7766 disodium is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities.

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STING

STING

STING Related Products (197)

Antibodies (13)

STING Related Products (197):