2. Signaling Pathways
  3. Immunology/Inflammation
  4. STING
  5. STING Modulator

STING Modulator

STING Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-148645
    STING modulator-4
    		Modulator
    STING modulator-4 (compound AIH05) is a competitive STING modulator with a Ki of 0.0933 μM for R232H STING. STING modulator-4 has an EC50 of >10 μM for p-IRF3 in THP-1 cell.
  • HY-148643
    STING modulator-5
    		Modulator
    STING modulator-5 (compound 38) is a STING modulator with a pIC50 value of 9.5. STING modulator-5 antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. STING modulator-5 is a antagonist of THP-1 cells, it can be used for immunological disease research.
  • HY-171012
    Clonixeril
    		Modulator
    Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTINGWT pathway at low femtomolar (10-15 M) and in some cases even attomolar (10-18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM.
  • HY-163643
    STING modulator-7
    		Modulator
    STING modulator-7 (compound 132) is a modulator of STING,.