2. Signaling Pathways
  3. Immunology/Inflammation
  4. SphK
  5. SphK Agonist

SphK Agonist

SphK Isoform Comparison

SphK Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-16621
    PPI-4955
    		Agonist
    PPI-4955 is a subtype 1 (S1P₁) agonist of sphingosine-1-phosphate receptor with an EC50 of 1.62 nM. PPI-4955-P (the active phosphorylated form) exhibits excellent receptor selectivity and affinity, and the IC50 values for hS1P₁, hS1P₃, hS1P₄, and hS1P₅ are 0.23, 2000, 6.5, and 184 nM respectively. PPI-4955 has significantly improved in vivo phosphorylation efficiency, which can reduce lymphocytes and improve cardiovascular risk. PPI-4955 can be used in immunomodulation research.