2. Signaling Pathways
  3. Anti-infection
  4. SARS-CoV
  5. SARS-CoV Degrader

SARS-CoV Degrader

SARS-CoV Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-174233
    PROTAC SARS-CoV-2 Degrader-1
    		Degrader
    PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a SARS-CoV-2 MPro PROTAC degrader with a DC50 value of 4.7 μM. PROTAC SARS-CoV-2 Degrader-1 induces MPro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771).
  • HY-157805
    PROTAC SARS-CoV-2 Mpro degrader-2
    		Degrader
    PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM.
  • HY-158905
    MTDB-Alkyne
    		Degrader
    MTDB-Alkyne is an alkyne-containing click chemistry reagent. MTDB-Alkyne can be used to synthesize Proximity-Induced Nucleic Acid Degrader (PINAD) for the degradation of SARS-CoV-2 RNA.