Prostaglandin Receptor Agonist

Prostaglandin Receptor Agonists (167):

Cat. No.	Product Name	Effect	Purity

HY-175986

IP receptor agonist 1	Agonist
IP receptor agonist 1 (compound 6c-14S) is an orally active IP receptor agonist, with an IC₅₀ of 0.15 μM for inhibiting platelet aggregation induced by ADP (HY-W010918,300 μM) in rabbit platelet-rich plasma. IP receptor agonist 1 can be used for study of Pulmonary arterial hypertension.

HY-125626

8-iso-15-keto Prostaglandin F2α	Agonist
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD₂ of 5.8. 8-iso-15-keto Prostaglandin F2α mediates a weak relaxation of rats aorta rings at high concentration.

HY-106206

AL-6598	Agonist
AL-6598 is a partial agonist of the DP and EP prostaglandin receptors. AL-6598 reduces intraocular pressure and is used in glaucoma research.

HY-136696

11-Deoxy-16,16-dimethyl-PGE2	Agonist
11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress.

HY-79593S1

MRE-269-d₆	Agonist
MRE-269-d₆ is deuterium labeled MRE-269. MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

HY-N7748A

Epi-cryptoacetalide	Agonist
Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with K_i values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities.

HY-120973

Butaprost free acid	Agonist
Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling.

HY-116843

(15S)-15-Methylprostaglandin E2	Agonist
(15S)-15-Methylprostaglandin E2 ((15R)-15-Methyl-PGE) is a prostaglandin E2 analog with the potential to prevent gastrointestinal bleeding and protect gastrointestinal cells.

HY-B0191S1

Bimatoprost-d₄	Agonist
Bimatoprost-d₄ is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.

HY-121091

EP2 receptor agonist 4	Agonist
EP2 receptor agonist 4 is a selective agonist for EP2 receptor with an EC₅₀ of 43 nM.

HY-W746807

Bimatoprost cyclohexyl amide	Agonist
Bimatoprost cyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide) is an analog of bimatoprost (HY-B0191). Bimatoprost cyclohexyl amide is an agonist of the prostaglandin F2α receptor. Bimatoprost cyclohexyl amide is used in research on reducing intraocular pressure and glaucoma.

HY-116250

Prostaglandin D2-1-glyceryl ester	Agonist
Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester).

HY-19641

AH13205	Agonist
AH13205 is a selective prostanoid EP₂-receptor agonist. AH13205 causes concentration-related relaxations of Carbachol (HY-B1208)-contracted trachea. AH13205 causes dose-related protection against Histamine (HY-B1204)-induced increases in respiratory rate.

HY-137574

19(R)-Hydroxy prostaglandin E1	Agonist
19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations.

HY-19255

FK-788	Agonist
FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC₅₀ of 18 nM and a high binding affinity for the human recombinant IP receptor, with a K_i value of 20 nM.

HY-123328

AGN 191976	Agonist
AGN 191976 is a potent and selective thromboxane A₂-sensitive (TP) receptor agonist with EC₅₀ values of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A₂ in vascular function.

HY-168382A

5S(6R)-EET	Agonist
5S(6R)-EET is the metabolite of Arachidonic acid (HY-109590). 5S(6R)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na⁺ absorption, increases the intracellular Ca²⁺, and promotes the depolarization of transmembrane voltage. 5S(6R)-EET is more active than 5R(6S)-EET (HY-168382).

HY-160993

Ciprostene	Agonist
Ciprostene is analog of prostacyclin (PGI2). Ciprostene inhibits adenosine diphosphate-induced platelet aggregation. Ciprostene can be used for research of peripheral vascular disease.

HY-14870R

Selexipag (Standard)	Agonist
Selexipag (Standard) is the analytical standard of Selexipag. This product is intended for research and analytical applications. Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI₂) receptor (IP receptor).

HY-16504S

Treprostinil-¹³C₂,d₁ Sodium	Agonist
Treprostinil-¹³C₂-d₁ (Sodium) (UT-15-¹³C₂-d₁(sodium)) is deuterium and ¹³C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

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