Prostaglandin Receptor Agonist

Prostaglandin Receptor Agonists (169):

Cat. No.	Product Name	Effect	Purity

HY-118556

Prostaglandin E2 serinol amide	Agonist
Prostaglandin E2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol. Prostaglandin E2 serinol amide is non-hydrolyzable to produce PGE2 and thus cannot inhibit leukotriene B4 biosynthesis, superoxide production, migration and antimicrobial peptide release.

HY-114793

AL-12180	Agonist
AL-12180 is a potent and selective FP-receptor agonist with a K_i of 143 nM. AL-12180 stimulates the mobilization of intracellular Ca²⁺ in h-TM and h-CM cells with EC₅₀s of 111 and 11 nM, respectively.

HY-116549

Prostaglandin F2α alcohol	Agonist
Prostaglandin F2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.

HY-142972

19(S)-HETE	Agonist
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC₅₀ value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.

HY-W714710

Teopranitol	Agonist
Teopranitol (KC-046), a coronary vasodilator with a rather selective venous dilatation, is used for the study of the acute myocardial ischemia.

HY-114587

RS 93427-007	Agonist
RS 93427-007 is an orally active prostacyclin stable mimetic agent. RS 93427-007 can be used for the research of cardiovascular disease, such as atherosclerosis.

HY-B0601R

Tafluprost acid (Standard)	Agonist
Tectoquinone (Standard) is the analytical standard of Tectoquinone. This product is intended for research and analytical applications. Tectoquinone (2-Methylanthraquinone) is a SARSCoV-2 main protease inhibitor against COVID-19. Tectoquinone exhibits strong mosquito larvicidal activity with the LC50 values of 3.3 and 5.4 μg/ml against A. aegypti and A. albopictus in 24 h, respectively.

HY-176022

U-46619 serinol amide	Agonist
U-46619 serinol amide is a derivative of U-46619 (HY-108566). U-46619 serinol amide is a stable analog of Thromboxane A2 (HY-113350) (TXA2). U-46619 serinol amide is a potent TXA2 agonist that can induce platelet shape change and aggregation.

HY-117659

PGDM	Agonist
PGDM (Prostaglandin D Metabolite) is the main urinary metabolite of Prostaglandin D2 and is prone to reversible cyclization. PGDM may serve as a biomarker for the endogenous production of PGD2 or be used to evaluate the severity of acute allergic reactions.

HY-139124

15(R)-15-Methyl Prostaglandin F2α	Agonist
15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.

HY-B0577R

Latanoprost (Standard)	Agonist
Latanoprost (Standard) is the analytical standard of Latanoprost. This product is intended for research and analytical applications. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

HY-B0584A

5,6-trans-Travoprost	Agonist
5,6-trans-Travoprost is the isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension.

HY-118648

Prostaglandin F2α methyl ester	Agonist
Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF_2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive.

HY-139121

15(R)-17-Phenyl trinor Prostaglandin F2α	Agonist
15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.

HY-116733

Tafluprost ethyl ester	Agonist
Tafluprost ethyl ester (AFP-175) is a derivative of Prostaglandin F2α (PGF2α) (HY-12956). Tafluprost ethyl ester is an agonist for prostaglandin FP receptor, and exhibits miotic effect.

HY-165434

Naxaprostene	Agonist
Naxaprostene is a prostacyclin analogue. Naxaprostene was much more selective for IP receptors and tended towards partial agonism. Naxaprostene inhibits ADP-induced platelet aggregation. It has been shown to prevent rabbit carotid artery thrombosis.

HY-123613

AGN192093	Agonist
AGN192093 is a TP agonist (EC₅₀ = 1.3 nM). AGN192093 exhibits potent and selective thromboxane analog activity in rat blood vessels.

HY-176011

17-Phenyl trinor prostaglandin F2α glycinamide methyl ester	Agonist
17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a derivative of Bimatoprost (HY-B0191) and a prostaglandin analog. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester is a human prostaglandin FP receptor agonist. 17-Phenyl trinor prostaglandin F2α glycinamide methyl ester has an ocular hypotensive effect and can be used in the study of ocular hypertension and glaucoma.

HY-116613

FR-181877	Agonist
FR-181877 (compound 4) is a non-prostaglandin PGI₂ agonist. FR-181877 inhibits ADP (HY-W010918)-induced human platelet aggregation with an IC₅₀ value of 0.081 μM.

HY-B0191S

Bimatoprost-d₅	Agonist	98.24%
Bimatoprost-d₅ is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect.

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