Pim

Pim Related Products (41):

By Effects:	Inhibitors (38) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-N1950

Hispidulin	Inhibitor	99.74%
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-101126

TP-3654	Inhibitor	99.96%
TP-3654 is a second-generation Pim kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

HY-13287

SGI-1776 free base	Inhibitor	99.96%
SGI-1776 free base is an inhibitor of Pim kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.

HY-18095

CX-6258	Inhibitor	98.06%
CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.

HY-12830

M-110	Inhibitor	99.05%
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC₅₀=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC₅₀s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC₅₀s of 0.6 to 0.9 μM.

HY-174803

WMJ-J-09	Activator
WMJ-J-09 is an HDAC inhibitor with IC₅₀ values of 7.5 nM (HDAC1), 21.3 nM (HDAC2), 18.4 nM (HDAC3), 90.9 nM (HDAC8), 3.9 nM (HDAC6) and 8715.7 nM (HDAC4). WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research^[1][2].

HY-W844558

Protein kinase inhibitor 11	Inhibitor	98.28%
Protein kinase inhibitor 11 (Compound I-96) is a protein kinase inhibitor that can inhibit the activity of PIM-1, CDK-2, GSK-3, and SRC. Protein kinase inhibitor 11 holds promise for research in cancer, immune disorders, and neurodegenerative diseases.

HY-175277

PIM1-IN-8	Inhibitor
PIM1-IN-8 is a PIM1/p65 pathway inhibitor. PIM1-IN-8 suppresses the expression of α-SMA and collagen I in activated fibroblasts and blocks TGF-β induced migration. PIM1-IN-8 alleviates pulmonary fibrosis in a Bleomycin (BLM) (HY-17565A)-induced pulmonary fibrosis mice model. PIM1-IN-8 can be used for the study of idiopathic pulmonary fibrosis (IPF).

HY-12929

NSC756093		99.58%
NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research.

HY-18095A

CX-6258 hydrochloride hydrate	Inhibitor	99.23%
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.

HY-18095B

CX-6258 hydrochloride	Inhibitor	99.03%
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.

HY-157169

IBL-302	Inhibitor	98.21%
IBL-302 (AMU302) is an orally available dual-signaling inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. IBL-302 demonstrated in vivo efficacy in a nude mouse xenograft model, inhibiting trastuzumab (HY-P9907) resistance challenges. IBL-302 also enhances the effects of common cytotoxic chemotherapy drugs cisplatin (HY-17394), doxorubicin (HY-15142A), and etoposide (HY-13629).

HY-129163

HJ-PI01	Inhibitor	99.72%
HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research.

HY-W412264

Pim-1/2 kinase inhibitor 1	Inhibitor	99.78%
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer.

HY-19322C

(1S,3R,5R)-PIM447 dihydrochloride	Inhibitor	99.81%
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC₅₀ values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

HY-162006

Pim-1 kinase inhibitor 8	Inhibitor	99.90%
Pim-1 kinase inhibitor 8 is a potent PIM-1 inhibitor with an IC₅₀ value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and autophagy. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC)-bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research.

HY-122665A

HTH-01-091 TFA	Inhibitor	99.48%
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 TFA also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 TFA can be uesd for breast cancer research.

HY-123141

K00135	Inhibitor	98.03%
K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets.

HY-147785

Pim-1 kinase inhibitor 2	Inhibitor
Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase. Pim-1 kinase inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases.

HY-156915

Pim-1 kinase inhibitor 13	Inhibitor
Pim-1 Kinase Inhibitor 13 (compound 10) is a Pim-1 kinase inhibitor with an IC₅₀ of 4.41 μM. Pim-1 Kinase Inhibitor 13 can be utilized in immunology or cancer research.

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