2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphoglycerate Kinase (PGK)

Phosphoglycerate Kinase (PGK)

Phosphoglycerate Kinase

Phosphoglycerate Kinase (PGK) is a key enzyme involved in glycolysis and gluconeogenesis. Currently, there are two isoenzymes of Phosphoglycerate Kinase, PGK1 and PGK2. Phosphoglycerate Kinase (PGK) catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP, producing 3-phosphoglycerate and ATP. This reaction is the first step in ATP production during glycolysis. Abnormal function of Phosphoglycerate Kinase (PGK) can disrupt cellular energy metabolism, thereby triggering and influencing the occurrence and development of various diseases, such as cancer, hemolytic anemia, neuromuscular dysfunction, etc[1].

Phosphoglycerate Kinase (PGK) Isoform Specific Products:

Phosphoglycerate Kinase (PGK) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W195984
    Z57346765
    		98.53%
    Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC).
    Z57346765
  • HY-N8540
    Ilicicolin H
    		Inhibitor
    Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection.
    Ilicicolin H
Phosphoglycerate Kinase (PGK) Isoform Comparison

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