2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Related Products

PDF 4.17 MB

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0312R
    Dipyridamole (Standard)
    		Inhibitor
    Dipyridamole (Standard) is the analytical standard of Dipyridamole. This product is intended for research and analytical applications. Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.
    Dipyridamole (Standard)
  • HY-109992
    LY 186126
    		Inhibitor
    LY 186126 a Indolidan analog, is a phosphodiesterase (PDE) inhibitor. LY 186126 binds to cardiac sarcoplasmic reticulum PDE with high affinity, with a Kd of 5.6 nM.
    LY 186126
  • HY-126206
    Quazodine
    		Inhibitor
    Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research.
    Quazodine
  • HY-15025S3
    Sildenafil-d5
    		Inhibitor
    Sildenafil-d5 (UK-92480-d5) is deuterium labeled Sildenafil. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
    Sildenafil-d<sub>5</sub>
  • HY-130748
    K-252d
    		Inhibitor
    K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).
    K-252d
  • HY-103267R
    S32826 disodium (Standard)
    		Inhibitor
    S32826 (disodium) (Standard) is the analytical standard of S32826 (disodium). This product is intended for research and analytical applications. S32826 disodium is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 disodium shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 disodium inhibits LPA release from adipocytes.
    S32826 disodium (Standard)
  • HY-134406
    6-Cl-cPuMP sodium
    		Modulator
    6-Cl-cPuMP (sodium) is a cAMP analog with active chlorine function. 6-Cl-cPuMP (sodium) has good membrane permeability and phosphodiesterase (PDE) stability. 6-Cl-cPuMP (sodium) can be used for nervous system research.
    6-Cl-cPuMP sodium
  • HY-123210R
    Lodenafil (Standard)
    		Inhibitor
    Lodenafil (Standard) is the analytical standard of Lodenafil. This product is intended for research and analytical applications. Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
    Lodenafil (Standard)
  • HY-119708S
    Ensifentrine-d6
    		Inhibitor
    Ensifentrine-d6 (RPL-554-d6) is deuterium labeled Ensifentrine. Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research.
    Ensifentrine-d<sub>6</sub>
  • HY-139095
    Cipamfylline
    		Inhibitor
    Cipamfylline is a PDE4 inhibitor that can cause PDE4A4 to accumulate in specific areas of the cell through interaction with the ubiquitin scaffolding protein p62. Cipamfylline can be used in the research of atopic dermatitis.
    Cipamfylline
  • HY-17464S2
    Cilostazol-d2
    		Inhibitor
    Cilostazol-d2 (OPC 13013-d2) is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM.
    Cilostazol-d<sub>2</sub>
  • HY-121491
    ONO-6126
    		Inhibitor
    ONO-6126 is a PDE4 inhibitor that can be used in research for asthma and chronic obstructive pulmonary disease.
    ONO-6126
  • HY-117605R
    N-Desmethyl Sildenafil (Standard)
    		Inhibitor
    N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
    N-Desmethyl Sildenafil (Standard)
  • HY-113892
    Leniquinsin
    		Inhibitor
    Leniquinsin is a phosphodiesterase inhibitor, which is used as a vasodilator.
    Leniquinsin
  • HY-19393
    SCH 351591
    		Inhibitor
    SCH 351591 is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 58 nM. SCH 351591 can inhibit all 4 PDE4 subtypes (A, B, C, and D). SCH 351591 has the potential for the asthma and chronic obstructive pulmonary disease (COPD) research.
    SCH 351591
  • HY-69172
    RS-25344
    		Inhibitor
    RS-25344 is a selective inhibitor of phosphodiesterase type IV (PDE4). RS-25344 increases intracellular cAMP (cyclic adenosine phosphate) concentration by inhibiting PDE4 activity. RS-25344 can be used in the study of inflammation, immune diseases, neurodegenerative diseases and cardiovascular diseases.
    RS-25344
  • HY-131473
    Desmethyl thiosildenafil
    		Inhibitor
    Desmethyl thiosildenafil is a phosphodiesterase type 5 (PDE5) inhibitor[1].
    Desmethyl thiosildenafil
  • HY-18252S2
    Avanafil-d4
    		Inhibitor
    Avanafil-d4 (TA1790-d4) is deuterium-labeled Avanafil (HY-18252).
    Avanafil-d<sub>4</sub>
  • HY-123145
    JNJ-10258859
    		Inhibitor
    JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a Ki of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research.
    JNJ-10258859
  • HY-131824
    5,6-DM-cBIMP
    		Agonist
    5,6-DM-cBIMP, a cyclic nucleotide analog, is an agonist of PDE2 that can significantly enhance the cAMP and cGMP hydrolytic activities of PDE2[2.
    5,6-DM-cBIMP
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.