2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. P-glycoprotein
  5. P-glycoprotein Antagonist

P-glycoprotein Antagonist

P-glycoprotein Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-106394
    TP-9201
    		Antagonist
    TP-9201 is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) (HY-W010918)-induced platelet aggregation in humans, baboons, and dogs (IC50 = 1-3 μM), while showing lower activity in rabbits (IC50 = 45 μM) and rats (IC50 = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis.