2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Oct3/4
  5. Oct3/4 Inhibitor

Oct3/4 Inhibitor

Oct3/4 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-133825
    Cyazofamid
    		Inhibitor 98.15%
    Cyazofamid exerts its bactericidal effect by impairing ATP production. Cyazofamid inhibits organic cation transporter 3 (OCT3) and OAT1, with IC50 values ​​of 1.54 and 17.3 μM, respectively.
  • HY-129108
    9-cis-UAB30
    		Inhibitor
    9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs). 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43). 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer.