2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Neprilysin

Neprilysin

Neutral endopeptidase; NEP; Cluster of differentiation 10; CD10

Neprilysin

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Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W009602R
    Phenylalanylalanine (Standard)
    		Inhibitor
    Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism.
    Phenylalanylalanine (Standard)
  • HY-17399R
    Racecadotril (Standard)
    		Inhibitor
    Racecadotril (Standard) is the analytical standard of Racecadotril. This product is intended for research and analytical applications. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
    Racecadotril (Standard)
  • HY-U00294
    NEP-In-1
    		Inhibitor
    NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.
    NEP-In-1
  • HY-101682
    SCH 42495
    		Inhibitor
    SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
    SCH 42495
  • HY-U00171
    SQ28603
    		Inhibitor
    SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
    SQ28603
  • HY-U00336
    NEP-IN-2
    		Inhibitor
    NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.
    NEP-IN-2
Cat. No. Product Name / Synonyms Species Source