2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113270A
    Actinine chloride
    		98.0%
    Actinine (γ-Butyrobetaine) chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
    Actinine chloride
  • HY-W012078
    5-Methyl-2'-deoxycytidine
    		99.87%
    5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells.
    5-Methyl-2'-deoxycytidine
  • HY-B1172
    Lactulose
    		99.90%
    Lactulose (4-O-β-D-Galactopyranosyl-D-fructose) is a poorly absorbed sugar that can be used to study constipation and hepatic encephalopathy. The drug generally begins to take effect 8 to 12 hours after administration, but it may take two days to improve constipation.
    Lactulose
  • HY-N1446S2
    Oleic acid-13C18
    		99.90%
    Oleic acid-13C18 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
    Oleic acid-<sup>13</sup>C<sub>18</sub>
  • HY-113219
    Hydroxyphenyllactic acid
    		99.95%
    Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid
  • HY-W010347S
    DL-Homocysteine-d4
    		98.4%
    DL-Homocysteine-d4 is the deuterium labeled DL-Homocysteine. DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.
    DL-Homocysteine-d<sub>4</sub>
  • HY-B0504S
    Creatinine-d3
    		99.90%
    Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.
    Creatinine-d<sub>3</sub>
  • HY-17461A
    Cortisone acetate
    		99.87%
    Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
    Cortisone acetate
  • HY-B1971
    Deltamethrin
    		99.93%
    Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.
    Deltamethrin
  • HY-W014102
    L-Alanyl-L-glutamine
    		98.0%
    L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations.
    L-Alanyl-L-glutamine
  • HY-B1384
    Retinyl palmitate
    		99.41%
    Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations.
    Retinyl palmitate
  • HY-113227
    Oxoadipic acid
    		99.86%
    Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
    Oxoadipic acid
  • HY-113486
    Lathosterol
    		98.09%
    Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury[1].
    Lathosterol
  • HY-16482
    Teglicar
    		Inhibitor ≥98.0%
    Teglicar is a selective and reversible orally active liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor with an IC50 value of 0.68 μM and a Ki value of 0.36 μM. Teglicar has a potential antihyperglycemic propert. Teglicar can be used for the research of diabetes and neurodegenerative disease including Huntington's disease (HD).
    Teglicar
  • HY-N1380
    Guaiacol
    		99.95%
    Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity.
    Guaiacol
  • HY-124489
    2-Hydroxyestradiol
    		98.05%
    2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity.
    2-Hydroxyestradiol
  • HY-117275
    Meclofenamic acid
    		99.66%
    Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively.
    Meclofenamic acid
  • HY-15129
    O-Phospho-L-serine
    		99.90%
    O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
    O-Phospho-L-serine
  • HY-N6612
    D-Glucuronic acid
    		98.0%
    D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity.
    D-Glucuronic acid
  • HY-19657
    Oxypurinol
    		99.94%
    Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol
Cat. No. Product Name / Synonyms Application Reactivity