2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-112160
    XL-784 free base
    		Inhibitor
    XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively.
    XL-784 free base
  • HY-NP123
    Highly purified Type II collagen, from porcine articular cartilage
    Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from porcine articular cartilage
  • HY-N1420R
    Rhamnose (Standard)
    		Inhibitor
    Amobam (Standard) is the analytical standard of Amobam. This product is intended for research and analytical applications. Amobam is a pesticidal.
    Rhamnose (Standard)
  • HY-N2117R
    Isoginkgetin (Standard)
    		Inhibitor
    Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.
    Isoginkgetin (Standard)
  • HY-N11643
    Ganoderic acid Mk
    		Inhibitor
    Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research.
    Ganoderic acid Mk
  • HY-RS08526
    Mmp13 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mmp13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp13 Mouse Pre-designed siRNA Set A
    Mmp13 Mouse Pre-designed siRNA Set A
  • HY-N4298
    Epitheaflagallin 3-O-gallate
    		Inhibitor
    Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts.
    Epitheaflagallin 3-O-gallate
  • HY-NP109
    Highly purified type I collagen, from mouse skin
    Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified type I collagen, from mouse skin
  • HY-12655
    IDE-IN-1
    		Inhibitor
    IDE-IN-1 (compound 6bK) is an insulin-degrading enzyme (IDE) inhibitor with IC50 value of 50 nM. IDE-IN-1 can be used to study type 2 diabetes.
    IDE-IN-1
  • HY-P6183
    LXJ-02
    		Inducer
    LXJ-02 is a potent inhibitor of EDPs/EBP peptide–protein interaction, with the KD of 117 μM for EDPs. LXJ-02 activates the macrophage-MMP-12 axis to increase MMP-12 expression and degrade ECM components like elastin.
    LXJ-02
  • HY-P2166
    MMP3 inhibitor 3
    		Inhibitor
    MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer.
    MMP3 inhibitor 3
  • HY-100211A
    (R)-TAPI-2
    		Control
    (R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP. TAPI-2 blocks the entry of infectious SARS-CoV.
    (R)-TAPI-2
  • HY-126956
    Porphyra 334
    Porphyra 334 is an antioxidative and anti-photoaging agent. Porphyra 334 suppresses ROS production and the expression of MMPs following UVA irradiation.
    Porphyra 334
  • HY-RS08539
    Mmp2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp2 Rat Pre-designed siRNA Set A
    Mmp2 Rat Pre-designed siRNA Set A
  • HY-NP125
    Highly purified Type IX collagen, from porcine articular cartilage
    Highly purified Type IX collagen, from porcine articular cartilage (Porcine Type IX collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type IX collagen, from porcine articular cartilage
  • HY-N10176
    D-Isofloridoside
    		Inhibitor
    D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9.
    D-Isofloridoside
  • HY-P1789
    CTTHWGFTLC, CYCLIC
    		Inhibitor
    CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM.
    CTTHWGFTLC, CYCLIC
  • HY-P2716
    Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2
    Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)
    Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2
  • HY-107640
    WAY-170523
    		Inhibitor
    WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research.
    WAY-170523
  • HY-RS08550
    Mmp3 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp3 Rat Pre-designed siRNA Set A
    Mmp3 Rat Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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