2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

PDF 1.48 MB

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-NP130
    Highly purified Type II collagen, from goat articular cartilage
    Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from goat articular cartilage
  • HY-RS00272
    Adam17 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Adam17 Mouse Pre-designed siRNA Set A
  • HY-153913
    MMP-9-IN-7
    		Inhibitor
    MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research.
    MMP-9-IN-7
  • HY-114581
    U27391
    		Inhibitor
    U27391 is a metalloproteinase inhibitor. U27391 inhibits rhIL-1β Induced proteoglycan loss.
    U27391
  • HY-137521
    Z-PDLDA-NHOH
    Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase.
    Z-PDLDA-NHOH
  • HY-122483
    Diethyl pyimDC
    		Inhibitor
    iethyl pyimDC is a collagen prolyl 4-hydroxylase (CP4H1) inhibitor inhibitor with the IC50 of 2.6μM. Diethyl pyimDC can be used for study of antifibrotic and antimetastatic.
    Diethyl pyimDC
  • HY-P4905
    Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2
    		Inhibitor
    Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*105 M-1s-1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*105 M-1s-1) and MMP9 (0.33*105 M-1s-1).
    Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2
  • HY-121096
    Funalenone
    		Inhibitor
    Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM.
    Funalenone
  • HY-NP122
    Highly purified Type I collagen, from porcine skin
    Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type I collagen, from porcine skin
  • HY-149725
    proMMP-9 selective inhibitor-1
    		Inhibitor
    proMMP-9 selective inhibitor-1 (compound 33) is a highly potent and selective inhibitor of proMMP-9 activation.
    proMMP-9 selective inhibitor-1
  • HY-146216
    MMP-9-IN-3
    		Inhibitor
    MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers.
    MMP-9-IN-3
  • HY-RS08559
    Mmp9 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp9 Rat Pre-designed siRNA Set A
  • HY-12168B
    (Rac)-Tanomastat
    		Inhibitor
    (Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.
    (Rac)-Tanomastat
  • HY-RS08553
    Mmp7 Rat Pre-designed siRNA Set A
    		Inhibitor

    Mmp7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp7 Rat Pre-designed siRNA Set A
  • HY-175276
    JNK-IN-24
    		Inhibitor
    JNK-IN-24, a JNK inhibitor, is an anti-metastatic cancer agent. JNK-IN-24 downregulates JNK and MMP1 expression in Scrib knockdown induced cancer tissues. JNK-IN-24 promotes recovery from tumorous wing disc phenotype of ScribRNAi. JNK-IN-24 can be used for the study in various epithelial cell-derived cancers.
    JNK-IN-24
  • HY-N15588
    Smyrindiol
    		Inhibitor
    Smyrindiol is a compound found in Dorstenia turbinate. Smyrindiol exerts anti-inflammatory and antimicrobial activities by inhibiting the secretion of tumor-associated proteases (MMP-2). Smyrindiol can be used in the study of brain tumors such as glioblastoma.
    Smyrindiol
  • HY-NP115
    Highly purified Type XI collagen, from chick articular cartilage
    Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from chick articular cartilage
  • HY-P5380
    TNO211
    		Substrate
    TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm).
    TNO211
  • HY-162039
    MMP-11-IN-1
    MMP-11-IN-1 (compound 9) is a new class of phosphinate prodrug. MMP-11-IN-1 is a glycosyl ester of RXP03 and improves blood–brain barrier (BBB) behavior.
    MMP-11-IN-1
  • HY-N0735R
    Phellodendrine chloride (Standard)
    		Inhibitor
    Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride (HY-N0735). Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.
    Phellodendrine chloride (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.