2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MAGL
  5. MAGL Degrader

MAGL Degrader

MAGL Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-173369
    PROTAC MAGL degrader-1
    		Degrader
    PROTAC MAGL degrader-1 is an orally active PROTAC agent that simultaneously targets monoacylglycerol lipase (MAGL) and E3 ubiquitin ligase MDM2. PROTAC MAGL degrader-1 degrades MAGL and inhibits the binding of MDM2 to p53. PROTAC MAGL degrader-1 can partially penetrate the blood-brain barrier (BBB). PROTAC MAGL degrader-1 induces glioblastoma stem cells (GSCs) apoptosis. (E3 ligase ligand: HY-128837; target protein ligand + linker: HY-173370; target protein inhibitor: HY-15249).