2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin

Kinesin

Kinesin

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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162531
    KIF18A-IN-9
    		Inhibitor
    KIF18A-IN-9 (Compound 1) is a potent KIF18A inhibitor, with an IC50 value of 3.8 nM. KIF18A-IN-9 has anticancer activity, with IC50 values of less than 100 nM in OVCAR3 and MDA-MB-157 cells.
    KIF18A-IN-9
  • HY-168727
    KSP ligand 1
    KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research.
    KSP ligand 1
  • HY-162518
    Eg5-IN-3
    		Inhibitor
    Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).
    Eg5-IN-3
  • HY-RS07261
    KIF14 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF14 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    KIF14 Human Pre-designed siRNA Set A
  • HY-164980
    KIF18A-IN-16
    		Inhibitor
    KIF18A-IN-16 (Compound 15) is a fused ring KIF18A inhibitor. KIF18A-IN-16 can be used in oncology (e.g., colon, breast, lung cancer) studies.
    KIF18A-IN-16
  • HY-10084
    CK0106023
    		Inhibitor
    CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice.
    CK0106023
  • HY-50759S
    Ispinesib-d5
    		Inhibitor
    Ispinesib-d5 (SB-715992-d5) is a deuterium labeled Ispinesib (HY-50759). Ispinesib is a specific inhibitor of kinesin spindle protein (KSP).
    Ispinesib-d<sub>5</sub>
  • HY-178511
    KIF18A-IN-17
    		Inhibitor
    KIF18A-IN-17 (Example 37A) is a KIF18A inhibitor with racemic form. KIF18A-IN-17 can be used for the study of cancers such as breast cancer and ovarian cancer.
    KIF18A-IN-17
  • HY-161898
    CENP-E-IN-3
    		Inhibitor
    CENP-E-IN-3 (compound 4) is a potent CENP-E inhibitor. CENP-E-IN-3 has the potential for the research of cancer.
    CENP-E-IN-3
  • HY-117440
    4'-Methoxy-S-trityl-L-cysteinol
    		Inhibitor
    4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.
    4'-Methoxy-S-trityl-L-cysteinol
  • HY-124823
    Monastroline
    		Inhibitor
    Monastroline (HR22C16) is an effective and selective inhibitor of the mitotic kinesin Eg5, exhibiting strong cell permeability.
    Monastroline
  • HY-157338
    NHS-Ala-Ala-Asn-active metabolite
    		Inhibitor
    NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor.
    NHS-Ala-Ala-Asn-active metabolite
  • HY-50759R
    Ispinesib (Standard)
    		Inhibitor
    Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
    Ispinesib (Standard)
  • HY-110090
    UA62784
    		Inhibitor
    UA62784 is a microtubule polymerization inhibitor that interacts with tubulin dimers. UA62784 is a novel specific inhibitor of centromere protein E (CENP-E) kinesin. UA62784 can be used for the study of pancreatic cancer.
    UA62784
Cat. No. Product Name / Synonyms Application Reactivity
Kinesin Isoform Comparison

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