2. Signaling Pathways
  3. Epigenetics
  4. Histone Methyltransferase
  5. NSD2/MMSET/WHSC1 Isoform
  6. NSD2/MMSET/WHSC1 Degrader

NSD2/MMSET/WHSC1 Degrader

NSD2/MMSET/WHSC1 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-141877
    MS4322
    		Degrader 99.14%
    MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 )).
  • HY-178322
    UNC10415667
    		Degrader
    UNC10415667 is a NSD2 degrader, with a DC50 values of 460 nM. UNC10415667 can be used for the study of cancers driven by NSD2 overexpression or dysregulation, such as multiple myeloma, acute lymphocytic leukemia, and prostate cancer.