Histone Acetyltransferase Inhibitor

Histone Acetyltransferase Inhibitors (122):

Cat. No.	Product Name	Effect	Purity

HY-175180

Conophyllidine	Inhibitor
Conophyllidine, a bisindole alkaloid, is a selective M2 polarization inhibitor. Conophyllidine inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. Conophyllidine inhibits IL-4-induced arginase with an IC₅₀ of 0.31 μM. Conophyllidine effectively induces a phenotypic switch in tumor-associated macrophages (TAMs) from an anti-inflammatory to an inflammatory type, thereby enhancing cytotoxic CD8⁺ T cell recruitment and functionality within the tumor microenvironment. Conophyllidine can be used for the study of TAMs.

HY-162995

KAT6A-IN-2	Inhibitor
KAT6A-IN-2 (compund 7) is a KAT6A inhibitor.

HY-138945

SYY-B085-1	Inhibitor
SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor extracted from patent WO2019201291A1.

HY-162997

KAT6-IN-3	Inhibitor
KAT6-IN-3 (compund 10) competitively targets KAT6A and KAT6B.

HY-178486

SH6	Inhibitor
SH6 is a transcription factor ZBTB7A degrader. SH6 is promising for research of β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia.

HY-162921

KAT6-IN-2	Inhibitor
KAT6-IN-2 (Compound 25) is a potent KAT6 inhibitor. KAT6-IN-2 is promising for research of cancers.

HY-N2020R

Anacardic Acid (Standard)	Inhibitor
Anacardic Acid (Standard) is the analytical standard of Anacardic Acid. This product is intended for research and analytical applications. Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ～8.5 μM and ～5 μM, respectively.

HY-177445

KAT6-IN-4	Inhibitor
KAT6-IN-4 (Compound Example 2) is a selective lysine acetyltransferase 6 (KAT6) inhibitor. KAT6-IN-4 suppresses transcription of oncogenes like ERα. KAT6-IN-4 demonstrates potent antitumor efficacy in ER⁺/HER2^- breast cancer xenografts. KAT6-IN-4 is promising for research of KAT6-driven malignancies (e.g., breast cancer, NSCLC).

HY-103669

HAT-IN-1	Inhibitor
HAT-IN-1 is an inhibitor of HAT, used in the research of cancer.

HY-128362

Ep300/CREBBP-IN-8	Inhibitor
Ep300/CREBBP-IN-8 (Example 37) is a potent and orally active Ep300 and CREBBP inhibitor with IC₅₀s of 0.014 and 0.018 μM, respectively. Ep300/CREBBP-IN-8 can be used for the research of cancer.

HY-159587

P300-IN-4	Inhibitor
P300-IN-4 (compound 6) is a (p300) inhibitor with the IC₅₀ of 12.2 μM.

HY-176251

CBP/p300-IN-22	Inhibitor
CBP/p300-IN-22 is a selective CBP/EP300-BRD inhibitor with an IC₅₀ of 4 nM. CBP/p300-IN-22 is highly selective over BRD4(1). CBP/p300-IN-22 reduces TNF-α-induced cytokine expression and subsequent immune cell recruitment by inhibiting NF-κB signaling, and has anticancer activity. CBP/p300-IN-22 can be used for the research of rheumatoid arthritis (RA) and other TNF-α-mediated inflammatory conditions.

HY-RS07080

KAT5 Human Pre-designed siRNA Set A	Inhibitor
KAT5 Human Pre-designed siRNA Set A contains three designed siRNAs for KAT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-146277

CBP/p300-IN-19	Inhibitor
CBP/p300-IN-19 is a potent p300/CBP HAT inhibitor with IC₅₀s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 shows antitumor activity.

HY-125969

Rtt109 inhibitor 1	Inhibitor
Rtt109 inhibitor 1 (Compound 1) is an inhibitor for histone acetyltransferase Rtt109 through a tight binding, uncompetitive system. Rtt109 inhibitor 1 exhibits antifungal activity through acetylation at H3K56 site.

HY-124892A

Acetylethylcholine mustard hydrochloride	Inhibitor
Acetylethylcholine mustard hydrochloride (Acetyl-AF64) is an inhibitor of choline acetyl-transferase that reduces the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC₅₀) of 1.22 mM. Acetylethylcholine mustard hydrochloride is an irreversible ligand for the high affinity choline transport system. Acetylethylcholine mustard hydrochloride is also a cholinotoxin. Acetylethylcholine mustard hydrochloride is a precursor for ethylcholine mustard aziridinium ion.

HY-139804

CTK7A	Inhibitor
CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer treatment research.

HY-123009

KCN1	Inhibitor
KCN1 is a p300/HIF-1α interaction inhibitor. KCN1 inhibits HIF transcriptional activity by binding to the CH1 domain of p300 and preventing the p300/HIF-1α assembly. KCN1 exerts antitumor activities through cell cycle arrest.

HY-66005S5

Acetaminophen-d₅	Inhibitor
Acetaminophen-d₅ is deuterated-labeled Acetaminophen (HY-66005). Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-N0005S1

Curcumin-d₃	Inhibitor
Curcumin-d₃ (Diferuloylmethane-d₃ ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

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