Hedgehog Inhibitor

Hedgehog Inhibitors (57):

Cat. No.	Product Name	Effect	Purity

HY-10440

Vismodegib	Inhibitor	99.97%
Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC₅₀ of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC₅₀ values of 3.0 μM and 1.4 μM, respectively.

HY-122632

Ciliobrevin D	Inhibitor	99.36%
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.

HY-100224

SANT-1	Inhibitor	99.87%
SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.

HY-110326

Smo antagonist M25	Inhibitor
Smo antagonist M25 is a smoothened antagonist for inhibition of the hedgehog pathway.

HY-177291

LAB687	Inhibitor
LAB687 (Compound 2a) is a Microsomal triglyceride transfer protein (MTP) inhibitor with an IC₅₀ of 0.9  nM for the secretion of apoB from HepG2 cells. LAB687 is also a Smoothened (Smo) antagonist with IC₅₀s of 2.48 and 3.42 μM for mouse and human Smo receptor, respectively. LAB687 can lower the level of triglycerides and LDL cholesterol and inhibits the Hedgehog signaling pathway.

HY-121802

Dynarrestin	Inhibitor	98.18%
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.

HY-100790

Ciliobrevin A	Inhibitor	98.57%
Ciliobrevin A (HPI-4) is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC₅₀) less than 10 μM.

HY-100515

Robotnikinin	Inhibitor	98.98%
Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo.

HY-N6954

Garcinone C	Inhibitor	99.66%
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.

HY-18366A

RU-SKI 43 hydrochloride	Inhibitor	99.55%
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity.

HY-B0508

Ornidazole	Inhibitor	99.58%
Ornidazole (Ro 7-0207) is a nitroimidazole derivative with anti-trichomonad activity and in vitro activity against a variety of anaerobic bacteria. Ornidazole inhibits Sonic hedgehog (Shh) signaling pathway, exhibits antitumor activity. Ornidazole can be used in research of Crohn’s disease.

HY-13307

JK184	Inhibitor	99.93%
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC₅₀ of 30 nM in mammalian cells.

HY-N0836

Jervine	Inhibitor	99.28%
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties.

HY-107551

Hh Pathway-IN-1	Inhibitor	99.06%
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC₅₀ value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner.

HY-15398C

3-epi-Vitamin D3	Inhibitor
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC₅₀ of 39.2 μM measured in U87MG cells.

HY-113965

CUR61414	Inhibitor	99.04%
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC₅₀ =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a K_i value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.

HY-158059

DS-1-38	Inhibitor	99.60%
DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB).

HY-122814

Hedgehog IN-1	Inhibitor	≥99.0%
Hedgehog IN-1 (Compound 7d) is an inhibitor for Hedgehog protein with IC₅₀ of 70 nM.

HY-16475

TAK-441	Inhibitor	98.47%
TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC₅₀value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors.

HY-N0247

Saikosaponin B1	Inhibitor	99.42%
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB).

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